2026-04-23T08:10:14Zhttps://repository.urosario.edu.co/oai/request

oai:repository.urosario.edu.co:10336/284162021-06-03T00:49:47Zcom_10336_39998com_10336_563col_10336_683

Anaya, Juan-Manuel Corre, Paula A. Herrera, Monica Eskdale, Joyce Gallagher, Grant 2020-08-28T15:48:09Z 2020-08-28T15:48:09Z 2002 Objective. To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren’s syndrome (pSS). Methods. Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. Results. IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 ± 6.7 vs 2.5 ± 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (< 9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. Conclusion. Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism. (J Rheumatol 2002;29:1874–6). application/pdf ISSN: 0315-162X EISSN: 1499-2752 https://repository.urosario.edu.co/handle/10336/28416 eng The Journal of Rheumatology Publishing 1876 No. 9 1874 The Journal of Rheumatology Vol. 29 The Journal of Rheumatology, ISSN: 0315-162X ; EISSN: 1499-2752, Vol. 29, No. 9 (2002); pp. 1874-1876 https://www.jrheum.org/content/jrheum/29/9/1874.full.pdf info:eu-repo/semantics/openAccess Abierto (Texto Completo) The Journal of Rheumatology instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR Sjögren’s Syndrome Interleukin 10 Anti-Ro Antibodies Anti-La Antibodies Rheumatoid Factor Polymorphism Genetics Interleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism La interleucina 10 (IL-10) influye en la respuesta autoinmune en el síndrome de Sjögren primario y está relacionada con el polimorfismo del gen IL-10 article info:eu-repo/semantics/publishedVersion Artículo