2026-04-26T20:36:41Zhttps://repository.urosario.edu.co/oai/request

oai:repository.urosario.edu.co:10336/284462021-06-03T00:49:49Zcom_10336_39998com_10336_563col_10336_683

Espinosa, Ana Mar??a Sierra, Adriana Yanett Barrero, Carlos Alberto Cepeda, Libia Alexandra Cantor, Elvia Mar??a Lombo, Tania Bibiana Guzmán, Fanny Avila, Sandra Julieta Patarroyo, Manuel A. 2020-08-28T15:48:13Z 2020-08-28T15:48:13Z 2003-03-07 Among the four parasite species causing malaria in humans, Plasmodium vivax prevails on both the Asian and the American continents. Several antigens from this parasite’s erythrocytic stages have been characterised and some of them are considered to be good vaccine candidates. The P. vivax merozoite surface protein-1 (PvMSP-1) is a 200 kDa antigen, thought to mediate the initial contact between the merozoite and the erythrocyte. An effective blockage of this interaction could be important in anti-malarial vaccine design. This study analyses the genetic polymorphism, binding to both reticulocytes and erythrocytes, antigenicity and immunogenicity of two recombinant proteins belonging to the 33 kDa PvMSP-1 proteolytic fragment. Both regions showed very low genetic variation, bound reticulocytes with higher affinity than erythrocytes, were recognised by naturally P. vivax-infected patient sera and were immunogenic when used to immunise rabbits, making them good vaccine candidates against P. vivax, to be further preclinically tested in the Aotus monkey model. application/pdf https://doi.org/10.1016/S0264-410X(02)00660-6 ISSN: 0264-410X EISSN: 1873-2518 https://repository.urosario.edu.co/handle/10336/28446 eng Elsevier 1043 No. 11–12 1033 Vaccine Vol. 21 Vaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol. 21, No. 11–12 (7 March 2003); pp. 1033-1043 https://www.sciencedirect.com/science/article/pii/S0264410X02006606?via%3Dihub info:eu-repo/semantics/restrictedAccess Restringido (Acceso a grupos específicos) Vaccine instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR Plasmodium vivax MSP-1 Binding Polymorphism Expression, polymorphism analysis, reticulocyte binding and serological reactivity of two Plasmodium vivax MSP-1 protein recombinant fragments Expresión, análisis de polimorfismo, unión de reticulocitos y reactividad serológica de dos fragmentos recombinantes de la proteína Plasmodium vivax MSP-1 article info:eu-repo/semantics/publishedVersion Artículo