Ítem
Acceso Abierto
Búsqueda de mutaciones en el gen foxo4 en pacientes con falla ovárica prematura no-sindrómica
Título de la revista
Autores
Garzón Venegas, Eliana del Pilar
Archivos
Fecha
2015-07-31
Directores
Fonseca Mendoza, Dora Janeth
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Editor
Universidad del Rosario
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Resumen
Abstract
FOXO4 constitutes a coherent candidate gene associated with premature ovarian failure (POF) pathogenesis. This study sequenced the coding and exon-flanking regions of this gene in a panel of 116 POF patients and 143 controls of Tunisian origin. In both groups, the IVS2 + 41T > G sequence variant was identified. It is concluded that coding mutations of FOXO4 should not be a common cause of the disease in women from the Tunisian population. However, this study cannot exclude that FOXO4 dysfunctions, originated from open reading frame or promoter sequence variations, might be associated with the pathogenesis of the disease in other ethnical groups.
Palabras clave
Female infertility , FOXO4 , Premature ovarian failure
