Deep Brain Stimulation for Tourette Syndrome

Peña, Camilo E; Faraji, Amir H

doi:https://doi.org/10.48713/10336_18313

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Acceso Abierto

Deep Brain Stimulation for Tourette Syndrome

http://repository.urosario.edu.co/handle/10336/18313
https://doi.org/10.48713/10336_18313

Autores

Peña, Camilo E

Faraji, Amir H

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Fecha

2018-06-13

Directores

Richardson, Mark

Editor

Universidad del Rosario

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Resumen

It has historically been difficult to arrive at an accurate diagnostic criterion or devise optimal medical and pharmacological strategies for the treatment of Tourette syndrome (TS). The International Tourette Syndrome Deep Brain Stimulation (DBS) Public Database and Registry is a multinational collaborative effort designed to share data and improve the quality of outcomes research in the treatment of TS with DBS. , recently described by Martinez-Ramirez et al in JAMA Neurology. The registry accumulated data from 171 patients. Stimulation sites included the centromedian thalamic region (57.1%), anterior globus pallidus internus (GPi; 25.2%) and posterior GPi (15.3%). There was a 40% improvement in the YGTSS total score at 6-mo (P < .001) and 45% at 12-mo (P < .001) without statistical difference between the 3 targets. The registry results mirror those described in a systematic review and meta-analysis of DBS for TS that was published in 2016. These data nonetheless should encourage movement disorder groups to consider treating refractory TS with DBS. The development of standardized surgical criteria will be helpful for identifying appropriate patients for evaluation.

Abstract

There was a 40% improvement in the YGTSS total score at 6-mo (P < . 001) and 45% at 12-mo (P < . 001) without statistical difference between the 3 targets. The registry results mirror those described in a systematic review and meta-analysis of DBS for TS that was published in 2016. These data nonetheless should encourage movement disorder groups to consider treating refractory TS with DBS. The development of standardized surgical criteria will be helpful for identifying appropriate patients for evaluation.