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Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena
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Petermann, Fanny
Villagrán, Marcelo
Troncoso, Claudia
Mardones, Lorena
Leiva, Ana María
MartÍnez, María Adela
Garrido-Méndez, Alex
Poblete-Valderrama, Felipe
Salas-Bravo, Carlos
Ramírez-Vélez, Robinson
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2018
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Resumen
La obesidad es una enfermedad crónica, recurrente y progresiva que se ha transformado rápidamente en una epidemia mundial. Según datos de la Organización Mundial de la Salud (OMS), en el año 2014 más de 600 millones de adultos a nivel mundial presentaban esta enfermedad, estimándose que las cifras aumentarán para el año 2030. En Chile, de acuerdo a datos de la Encuesta Nacional de Salud 2016-2017, 74,2% de la población presenta sobrepeso u obesidad, lo que posiciona a Chile como el país que lidera el ranking de obesidad en América Latina y como uno de los diez países que presenta mayor obesidad a nivel mundial--Tomado del texto.
Abstract
Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors. © 2018, Sociedad Medica de Santiago. All rights reserved.
Palabras clave
Alpha Ketoglutarate Dependent Dioxygenase Fto , Fto Protein , Allele , Anthropometry , Chile , Cross-Sectional Study , Ethnology , Genetic Marker , Genetic Predisposition , Genetics , Genotype , Human , Lifestyle , Male , Obesity , Polymerase Chain Reaction , Reference Value , Risk Factor , Single Nucleotide Polymorphism , Socioeconomics , Statistical Model , Young Adult , Adiposity , Alleles , Alpha-Ketoglutarate-Dependent Dioxygenase Fto , Anthropometry , Chile , Cross-Sectional Studies , Genetic Markers , Genetic Predisposition To Disease , Genotype , Life Style , Linear Models , Male , Obesity , Polymerase Chain Reaction , Polymorphism , Reference Values , Socioeconomic Factors , Young Adult , Alfa cetoglutarato dependiente dioxigenasa F , La proteína FTO , Alelo
Keywords
Adult , Female , Middle Aged , Adult , Female , Humans , Middle Aged , Risk Factors
