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Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1 ∗ PBRs in Fully-Protective Malaria Vaccine Components
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Bermudez, Adriana
Alba, Martha P.
Vanegas, Magnolia
Patarroyo, Manuel A.
Patarroyo, Manuel E.
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2018
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Abstract
The 3D structural analysis of 62 peptides derived from highly pathogenic Plasmodium falciparum malaria parasite proteins involved in host cell invasion led to finding a striking association between particular β-turn types located in the N-terminal peripheral flanking residue region (preceding the polyproline II left-handed structures fitting into the HLA-DRβ* allele family) and modified immune protection-inducing protein structure induced long-lasting protective immunity. This is the first time association between two different secondary structures associated with a specific immunological function has been described: full, long-lasting protective immunity. © 2018 Bermudez, Alba, Vanegas, Patarroyo and Patarroyo.
Palabras clave
Vacuna contra la malaria
Keywords
β-turns , Structure-function , IMPIPS , LLPI , PPIIL , Malaria vaccine
