Ítem
Acceso Abierto
The coexistence of antiphospholipid syndrome and systemic lupus erythematosus in Colombians
Título de la revista
Autores
Franco, Juan-Sebastian
Molano González, Nicolás
Rodríguez Jiménez, Mónica María del Pilar
Acosta Ampudia, Yeny Yasbleidy
Mantilla, Rubén D.
Amaya-Amaya, Jenny
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
Archivos
Fecha
2014
Directores
ISSN de la revista
Título del volumen
Editor
Buscar en:
Métricas alternativas
Resumen
Abstract
Objectives: To examine the prevalence and associated factors related to the coexistence of antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in a cohort of Colombian patients with SLE, and to discuss the coexistence of APS with other autoimmune diseases (ADs).Method: A total of 376 patients with SLE were assessed for the presence of the following: 1) confirmed APS; 2) positivity for antiphospholipid (aPL) antibodies without a prior thromboembolic nor obstetric event; and 3) SLE patients without APS nor positivity for aPL antibodies. Comparisons between groups 1 and 3 were evaluated by bivariate and multivariate analysis.Results: Although the prevalence of aPL antibodies was 54%, APS was present in just 9.3% of SLE patients. In our series, besides cardiovascular disease (AOR 3.38, 95% CI 1.11-10.96, p = 0.035), pulmonary involvement (AOR 5.06, 95% CI 1.56- 16.74, p = 0.007) and positivity for rheumatoid factor (AOR 4.68, 95%IC 1.63-14.98, p = 0.006) were factors significantly associated with APS-SLE. APS also may coexist with rheumatoid arthritis, Sjö gren's syndrome, autoimmune thyroid diseases, systemic sclerosis, systemic vasculitis, dermatopolymyositis, primary biliary cirrhosis and autoimmune hepatitis.Conclusions: APS is a systemic AD that may coexist with other ADs, the most common being SLE. Awareness of this polyautoimmunity should be addressed promptly to establish strategies for controlling modifiable risk factors in those patients. © 2014 Franco et al.
Palabras clave
Anticuerpo fosfolípido , Adulto , Síndrome antifosfolípido
Keywords
Phospholipid antibody , Rheumatoid factor , Adult , Antibody titer , Antiphospholipid syndrome
