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Evaluation of a Cryptococcal antigen lateral flow assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia
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Cáceres, Diego H.
Zuluaga, Alejandra
Tabares, Ángela M.
Chiller, Tom
González, Ángel
Gómez, Beatriz L.
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2017
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Abstract
A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen. © 2017, Instituto de Medicina Tropical de Sao Paulo. All rights reserved.
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Keywords
Article , Human , Cryptococcosis , Cryptococcus , Antigen , Diagnosis , Point-of-care , Lateral Flow Assay , Immunochromatographic assay , Latex agglutination system
