Ítem
Solo Metadatos

Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members

Título de la revista
Autores
Krause, Ilan
Anaya, Juan-Manuel
Fraser, Abigail
Barzilai, Ori
Ram, Maya
Abad, Verónica
Arango, Alvaro
García, Jorge
Shoenfeld, Yehuda

Fecha
2009

Directores

ISSN de la revista
Título del volumen
Editor
Blackwell Publishing Inc.

Buscar en:

Métricas alternativas

Resumen
Abstract
Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P = 0.01), cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue transglutaminase antibodies (P = 0.03), and a borderline association with anticentromere antibodies (P = 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies. © 2009 New York Academy of Sciences.
Palabras clave
Keywords
Autoantibody , Bacterium antibody , Cardiolipin antibody , Centromere antibody , Cytomegalovirus antibody , Double stranded dna antibody , Epstein barr virus antibody , Gliadin antibody , Glomerulus basement membrane antibody , Helicobacter pylori antibody , Hepatitis b virus antibody , Immunoglobulin a , Immunoglobulin g , Immunoglobulin g antibody , Jo 1 antibody , La antibody , Myeloperoxidase antibody , Protein glutamine gamma glutamyltransferase antibody , Proteinase 3 antibody , Prothrombin antibody , Protozoon antibody , Ribonucleoprotein antibody , Ro antibody , Rubella antibody , Scl 70 antibody , Sm antibody , Toxoplasma antibody , Unclassified drug , Virus antibody , Adolescent , Age distribution , Antibody blood level , Celiac disease , Conference paper , Controlled study , Cytomegalovirus , Diabetic patient , Disease association , Epstein barr virus , Family , Female , Helicobacter pylori , Hepatitis b virus , Hepatitis c virus , Human , Infection sensitivity , Insulin dependent diabetes mellitus , Major clinical study , Male , Nonhuman , Rubella , Toxoplasma , Treponema pallidum , Cytomegalovirus , Helicobacter pylori , Human herpesvirus 4 , Toxoplasma , Autoimmunity , Celiac disease , Cytomegalovirus , Epstein-barr virus , Helicobacter pylori , Infection , Toxoplasma
Buscar en:
Colecciones