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The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris
Título de la revista
Autores
Misas E.
Escandón P.
McEwen J.G.
Clay O.K.
Fecha
2019
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Blackwell Publishing Ltd
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Resumen
Abstract
The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris. © 2019 The Protein Society
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Keywords
Regulator protein , Single stranded dna binding protein , Transcription factor , Article , Candida auris , Drug resistance , Fungal virulence , Nonhuman , Priority journal , Protein domain , Protein structure , Structure analysis , Transcription initiation , Transcription regulation , Activation and repression domains , Amphotericin b , Antifungal resistance mechanisms , Candida , Filamentation in fungi , Flocculence , Lufs domain , Single nucleotide polymorphisms , Transcription factors , Whole-genome sequence comparisons
