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Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy
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Caceres, Diego H.
Scheel, Christina M.
Tobón, Ángela M.
Cleveland, Angela Ahlquist
Restrepo, Ángela
Brandt, Mary E.
Chiller, Tom
Gómez, Beatriz L.
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2014
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Abstract
We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
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Keywords
Amphotericin B deoxycholate , Fungus antigen , Histoplasma capsulatum antigen , Itraconazole , Unclassified drug , Fungus antigen , Acquired immune deficiency syndrome , Antigen detection , Article , Colombia , Enzyme linked immunosorbent assay , Follow up , Histoplasma capsulatum , Histoplasmosis , Human , Major clinical study , Nonhuman , Priority journal , Sensitivity and specificity , Treatment response , Urinalysis , Validation process , AIDS-Related Opportunistic Infections , Cohort analysis , Diagnostic procedure , Drug monitoring , Enzyme linked immunosorbent assay , Histoplasma , Histoplasmosis , Immunology , Procedures , Prospective study , Urine , Validation study , AIDS-Related Opportunistic Infections , Antigens , Clinical Laboratory Techniques , Cohort Studies , Colombia , Drug Monitoring , Enzyme-Linked Immunosorbent Assay , Histoplasma , Histoplasmosis , Humans , Prospective Studies , Sensitivity and Specificity
