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Trypanosoma cruzi I: Towards the need of genetic subdivision?, Part II
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Autores
Ramírez, Juan David
Hernández C.
Fecha
2018
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Editor
Elsevier B.V.
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Resumen
Abstract
Chagas disease is a complex zoonosis caused by the kinetoplastid parasite Trypanosoma cruzi. This protozoan exhibits remarkable genetic diversity evinced in at least six Discrete Typing Units (DTUs) with the foreseen emergence of a genotype associated to bats (TcBat). T. cruzi I is the DTU with the broadest geographical distribution and associated to severe cardiomyopathies. In 2011, we published a review questioning the need for genetic subdivision within TcI. However, after six years of intensive research. Herein, we attempted to determine if TcI should be subdivided or not in the light of the current genetic, biological, clinical and ecological data. The future perspectives are discussed. © 2017 Elsevier B.V.
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Keywords
Cardiovascular disease , Chagas disease , Genetic variation , Genotype , Geographical distribution , Parasitic disease , Bat , Chagas cardiomyopathy , Chagas disease , Disease severity , Ecology , Genetic variability , Genomics , Genotype , Geographical variation (species) , Human , Nonhuman , Protozoal genetics , Review , Trypanosoma cruzi , Animal , Classification , Genetic variation , Genetics , Parasitology , Trypanosoma cruzi , Kinetoplastida , Protozoa , Trypanosoma cruzi , Animals , Chagas disease , Genetic variation , Genotype , Humans , Trypanosoma cruzi , Chagas disease , Dtus , Genotypes , Tci , Tcidom
