Sequence analysis of the CDKN1B gene in patients with premature ovarian failure reveals a novel mutation potentially related to the phenotype

Ojeda D.; Lakhal B.; Fonseca Mendoza, Dora Janeth; Braham R.; Landolsi H.; Mateus H.E.; Restrepo Fernández, Carlos Martín; Elghezal H.; Saâd A.; Laissue P.

doi:https://doi.org/10.1016/j.fertnstert.2011.04.045

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Acceso Abierto

Sequence analysis of the CDKN1B gene in patients with premature ovarian failure reveals a novel mutation potentially related to the phenotype

https://repository.urosario.edu.co/handle/10336/24059
https://doi.org/10.1016/j.fertnstert.2011.04.045

Autores

Ojeda D.

Lakhal B.

Fonseca Mendoza, Dora Janeth

Braham R.

Landolsi H.

Mateus H.E.

Restrepo Fernández, Carlos Martín

Elghezal H.

Saâd A.

Laissue P.

Archivos

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Fecha

2011

Editor

Elsevier Inc.

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Abstract

Earlier reports demonstrated a key role of Cdkn1b during mouse ovarian development. In this study, the sequencing analysis of the complete coding region of this gene in a panel of premature ovarian failure patients and control subjects reveals a novel mutation potentially related to the phenotype. © 2011 by American Society for Reproductive Medicine.

Keywords

Cyclin dependent kinase inhibitor 1B , Follitropin , Adult , Article , Autoimmune disease , Controlled study , Female , Female infertility , Follitropin blood level , Gene mutation , Genetic analysis , Genetic code , Human , Informed consent , Karyotype , Major clinical study , Ovary development , Ovary insufficiency , Pelvis surgery , Phenotype , Premature ovarian failure , Priority journal , Sequence analysis , Single nucleotide polymorphism , CDKN1B , Mutations , Premature ovarian failure (POF) , Sequencing