Ítem
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Convalescent plasma in Covid-19: Possible mechanisms of action.
Título de la revista
Autores
Rojas Quintana, Manuel Eduardo
Rodríguez Velandia, Yhojan Alexis
Monsalve Carmona, Diana Marcela
Acosta Ampudia, Yeny Yasbleidy
Camacho, Bernardo
Gallo, Juan Esteban
Rojas-Villarraga, Adriana
Ramírez Santana, Heily Carolina
Diaz-Coronado, Juan C
Manrique, Ruben
Fecha
2020
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Editor
Elsevier BV
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Resumen
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible of the coronavirus disease 2019 (COVID-19) pandemic. Therapeutic options including antimalarials, antivirals, and vaccines are under study. Meanwhile the current pandemic has called attention over old therapeutic tools to treat infectious diseases. Convalescent plasma (CP) constitutes the first option in the current situation, since it has been successfully used in other coronaviruses outbreaks. Herein, we discuss the possible mechanisms of action of CP and their repercussion in COVID-19 pathogenesis, including direct neutralization of the virus, control of an overactive immune system (i.e., cytokine storm, Th1/Th17 ratio, complement activation) and immunomodulation of a hypercoagulable state. All these benefits of CP are expected to be better achieved if used in non-critically hospitalized patients, in the hope of reducing morbidity and mortality.
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Keywords
ACE-2 receptor , COVID-19 , Convalescent plasma , Coronavirus , Cytokines , Intravenous immunoglobulins , Neutralizing antibodies , SARS-Cov-2
