Ítem
Acceso Abierto
Systemic lupus erythematosus 2014.
Título de la revista
Autores
Anaya, Juan-Manuel
Shoenfeld, Yehuda
Cervera, Ricard
Archivos
Fecha
2014
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Editor
Hindawi Publishing Corporation
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Resumen
Abstract
Systemic lupus erythematosus (SLE, lupus) is the prototype of systemic autoimmune disease (AD). Immune system activation in SLE is characterized by exaggerated B-cell and T-cell responses and loss of immune tolerance against self-antigens. Production and defective elimination of antibodies, circulation and tissue deposition of immune complexes, and complement and cytokine activation contribute to clinical manifestations that range from fatigue and joint pain to severe, life-threatening organ damage
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Keywords
Systemic lupus erythematosus , autoimmune disease , self-antigens