Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

Cubillos, Marcia; Alba, Martha Patricia; Bermudez, Adriana; Trujillo, Mary; Patarroyo, Manuel Elkin

doi:https://doi.org/10.1016/S0300-9084(03)00136-6

Ítem

Solo Metadatos

Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

https://repository.urosario.edu.co/handle/10336/26739
https://doi.org/10.1016/S0300-9084(03)00136-6

Autores

Cubillos, Marcia

Alba, Martha Patricia

Bermudez, Adriana

Trujillo, Mary

Patarroyo, Manuel Elkin

Fecha

2003-07

Editor

Société Française de Biochimie et Biologie Moléculaire (SFBBM)
Elsevier

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Abstract

Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides’ secondary structure and their function as immunogen against malaria.