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The Autoimmune Tautology: From Polyautoimmunity and Familial Autoimmunity to the Autoimmune Genes
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Autores
Anaya, Juan-Manuel
Rojas-Villarraga, Adriana
Garcıa-Carrasco, Mario
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Fecha
2012-03
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Universidad del Rosario
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Abstract
Autoimmune diseases (ADs) are chronic conditions initiated
by the loss of immunological tolerance to self-antigens and
represent a heterogeneous group of disorders that afflict specific
target organs ormultiple organ systems [1]. The chronic
nature of these diseases places a significant burden on the utilization
of medical care, direct and indirect economic costs,
and quality of life. The fact that ADs share several clinical
signs and symptoms (i.e., subphenotypes), physiopathological
mechanisms, and genetic factors has been called
autoimmune tautology and indicates that they have common
mechanisms