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Astroglial role in the pathophysiology of status epilepticus : an overview

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dc.contributor.gruplacGrupo de Neuro Ciencias de la Universidad del Rosario (Neuros)spa
dc.creatorVargas-Sánchez, Karina
dc.creatorMogilevskaya, Maria
dc.creatorRodríguez-Pérez, John
dc.creatorRodríguez-Pérez, John
dc.creatorRubiano, María G.
dc.creatorJavela, José J.
dc.creatorGonzález Reyes, Rodrigo Esteban
dc.creator.googleVargas-Sánchez, K., Mogilevskaya, M., Rodríguez-Pérez, J., Rubiano, M.G., Javela, J.J., González-Reyes, R.E.spa
dc.creator.googleVargas-Sánchez, Karina
dc.creator.googleMogilevskaya, Maria
dc.creator.googleRodríguez-Pérez, John
dc.creator.googleRubiano, María G.
dc.creator.googleJavela, José J.
dc.creator.googleGonzález-Reyes, Rodrigo E.
dc.date.accessioned2019-09-23T14:42:31Z
dc.date.available2019-09-23T14:42:31Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractStatus epilepticus is a medical emergency with elevated morbidity and mortality rates, and represents a leading cause of epilepsy-related deaths. Though status epilepticus can occur at any age, it manifests more likely in children and elderly people. Despite the common prevalence of epileptic disorders, a complete explanation for the mechanisms leading to development of self-limited or long lasting seizures (as in status epilepticus) are still lacking. Apart from neurons, research evidence suggests the involvement of immune and glial cells in epileptogenesis. Among glial cells, astrocytes represent an ideal target for the study of the pathophysiology of status epilepticus, due to their key role in homeostatic balance of the central nervous system. During status epilepticus, astroglial cells are activated by the presence of cytokines, damage associated molecular patterns and reactive oxygen species. The persistent activation of astrocytes leads to a decrease in glutamate clearance with a corresponding accumulation in the synaptic extracellular space, increasing the chance of neuronal excitotoxicity. Moreover, major alterations in astrocytic gap junction coupling, inflammation and receptor expression, facilitate the generation of seizures. Astrocytes are also involved in dysregulation of inhibitory transmission in the central nervous system and directly participate in ionic homeostatic alterations during status epilepticus. In the present review, we focus on the functional and structural changes in astrocytic activity that participate in the development and maintenance of status epilepticus, with special attention on concurrent inflammatory alterations. We also include potential astrocytic treatment targets for status epilepticus. © Vargas-Sánchez et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.18632/oncotarget.25485
dc.identifier.issn1949-2553
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/20312
dc.language.isoengspa
dc.relation.citationEndPage26976
dc.relation.citationStartPage26954
dc.relation.citationTitleOncotarget
dc.relation.citationVolumeVol. 9
dc.relation.ispartofOncotarget, ISSN:1949-2553, Vol. 9 (2018) pp. 26954-26976spa
dc.relation.urihttp://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=25485&path[]=79801spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationKroner, B.L., Fahimi, M., Gaillard, W.D., Kenyon, A., Thurman, D.J., Epilepsy or seizure disorder? The effect of cultural and socioeconomic factors on self-reported prevalence (2016) Epilepsy Behav, 62, pp. 214-217spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectAstrocytesspa
dc.subjectStatus epilepticusspa
dc.subjectEpilepsyspa
dc.subjectGliaspa
dc.subjectNeuroinflammationspa
dc.subject.ddcEnfermedadesspa
dc.subject.lembEpilepsiaspa
dc.subject.lembEnfermedades cerebralesspa
dc.subject.lembConvulsionesspa
dc.titleAstroglial role in the pathophysiology of status epilepticus : an overviewspa
dc.typerevieweng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaRevisiónspa
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