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Characterising PvRBSA: an exclusive protein from Plasmodium species infecting reticulocytes

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dc.creatorMoreno-Pérez, Darwin A.spa
dc.creatorBaquero, Luis A.spa
dc.creatorChitiva-Ardila, Diana M.spa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-25T23:57:49Z
dc.date.available2020-05-25T23:57:49Z
dc.date.created2017spa
dc.description.abstractBackground: Plasmodium vivax uses multiple ligand-receptor interactions for preferential invasion of human reticulocytes. Several of these ligands have been identified by in silico approaches based on the role displayed by their orthologs in other Plasmodium species during initial adhesion or invasion. However, the cell adhesion role of proteins that are exclusive to species that specifically invade reticulocytes (as P. vivax and P. cynomolgi) has not been evaluated to date. This study aimed to characterise an antigen shared between Plasmodium species that preferentially infect reticulocytes with a focus on assessing its binding activity to target cells. Results: An in silico analysis was performed using P. vivax proteome data to identify and characterise one antigen shared between P. vivax and P. cynomolgi. This led to identification of the pvrbsa gene present in the P. vivax VCG-I strain genome. This gene is transcribed in mature schizonts and encodes a protein located on the parasite surface. rPvRBSA was antigenic and capable of binding to a population of reticulocytes with a different Duffy phenotype. Interestingly, the molecule showed a higher percentage of binding to immature human reticulocytes (CD71hi). Conclusions: This study describes for the first time, a molecule involved in host cell binding that is exclusive in reticulocyte-infecting Plasmodium species. This suggest that PvRBSA is an antigenic adhesin that plays a role in parasite binding to target cells. © 2017 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s13071-017-2185-6
dc.identifier.issn17563305
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22750
dc.language.isoengspa
dc.publisherBioMed Central Ltd.spa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleParasites and Vectors
dc.relation.citationVolumeVol. 10
dc.relation.ispartofParasites and Vectors, ISSN:17563305, Vol.10, No.1 (2017)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85019549552&doi=10.1186%2fs13071-017-2185-6&partnerID=40&md5=e302c67ca99d2eae5b96956cc08a524cspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdhesinspa
dc.subject.keywordCd71 antigenspa
dc.subject.keywordDuffy binding proteinspa
dc.subject.keywordMembrane antigenspa
dc.subject.keywordProteomespa
dc.subject.keywordReticulocyte binding surface antigenspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordParasite antigenspa
dc.subject.keywordProteomespa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordAntigen bindingspa
dc.subject.keywordAntigenicityspa
dc.subject.keywordArticlespa
dc.subject.keywordBinding affinityspa
dc.subject.keywordCell interactionspa
dc.subject.keywordCell maturationspa
dc.subject.keywordCell populationspa
dc.subject.keywordCell transportspa
dc.subject.keywordComputer modelspa
dc.subject.keywordControlled studyspa
dc.subject.keywordGenespa
dc.subject.keywordGene identificationspa
dc.subject.keywordGenetic strainspa
dc.subject.keywordGenetic transcriptionspa
dc.subject.keywordGenomespa
dc.subject.keywordHost cellspa
dc.subject.keywordHost parasite interactionspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman cellspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPhenotypespa
dc.subject.keywordPlasmodiumspa
dc.subject.keywordPlasmodium cynomolgispa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPredictionspa
dc.subject.keywordProtein analysisspa
dc.subject.keywordProtein localizationspa
dc.subject.keywordProteomicsspa
dc.subject.keywordRbsa genespa
dc.subject.keywordReticulocytespa
dc.subject.keywordSchizontspa
dc.subject.keywordTarget cellspa
dc.subject.keywordCell adhesionspa
dc.subject.keywordErythrocytespa
dc.subject.keywordGeneticsspa
dc.subject.keywordHost pathogen interactionspa
dc.subject.keywordMetabolismspa
dc.subject.keywordParasitologyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordPlasmodiumspa
dc.subject.keywordPlasmodium vivax malariaspa
dc.subject.keywordReticulocytespa
dc.subject.keywordAntigens, protozoanspa
dc.subject.keywordCell adhesionspa
dc.subject.keywordErythrocytesspa
dc.subject.keywordGenes, protozoanspa
dc.subject.keywordHost-pathogen interactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordMalaria, vivaxspa
dc.subject.keywordPlasmodiumspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProteomespa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordReticulocytesspa
dc.subject.keywordAdhesinspa
dc.subject.keywordAntigenic proteinspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordReticulocytespa
dc.titleCharacterising PvRBSA: an exclusive protein from Plasmodium species infecting reticulocytesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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