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Familial disease, the HLA-DRB1 shared epitope and anti-CCP antibodies influence time at appearance of substantial joint damage in rheumatoid arthritis

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dc.creatorRojas-Villarraga, Adriana
dc.creatorDiaz, Francisco J.spa
dc.creatorCalvo-Páramo, Enriquespa
dc.creatorSalazar, Juan C.spa
dc.creatorIglesias-Gamarra, Antoniospa
dc.creatorMantilla, Ruben D.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-25T23:55:53Z
dc.date.available2020-05-25T23:55:53Z
dc.date.created2009spa
dc.description.abstractRheumatoid arthritis (RA) progresses more rapidly in some patients than in others and diverse factors influence radiographic progression in a specific population. Thus, we searched for variables that are associated with an early appearance of substantial joint damage in patients with RA by using radiographic assessments. A cohort of 157 consecutively enrolled Colombian RA patients was followed for an average of 3.2 ± 3.1 years. Information on patient demographics and cumulative clinical and laboratory manifestations over the course of the disease was registered, including family history of RA in first-degree relatives, extra-articular manifestations, rheumatoid factor, anti-CCP3 antibodies, TNF single nucleotide polymorphism at -308 position, and HLA-DRB1 status. Radiographs were scored according to the Sharp-van der Heijde method. Survival analyses of the time at appearance of substantial joint damage were performed by using Weibull models. A review of literature about the influence of familial RA on the progression of disease was done. Our results show that family history of RA is consistently associated with joint damage (i.e. erosive and joint narrowing disease). This effect was not found in all the populations reviewed. In addition, we confirm the effect of HLA-DRB1 shared epitope and anti-CCP seropositivity on erosive disease. Family history of RA is a key risk factor for joint damage and depends on the investigated population because variations in both additive and non-additive genetic factors and the environmental variance are specific to the population. Our results emphasize the usefulness of assessing familial disease, testing anti-CCP antibodies and genotyping HLA-DRB1 gene in patients with RA because these factors may be used to predict clinical outcomes and guide therapeutic interventions. © 2008 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2008.11.004
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22249
dc.language.isoengspa
dc.relation.citationEndPage69
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage64
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 32
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.32, No.1 (2009); pp. 64-69spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-58849141572&doi=10.1016%2fj.jaut.2008.11.004&partnerID=40&md5=575d08d44cf525bc32af5a4076ee2629spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordEpitopespa
dc.subject.keywordHla dr antigenspa
dc.subject.keywordcycliceng
dc.subject.keywordrheumatoideng
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordChildspa
dc.subject.keywordClinical featurespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease durationspa
dc.subject.keywordFamily historyspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordJoint injuryspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPreschool childspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSurvival timespa
dc.subject.keywordAdultspa
dc.subject.keywordAge of onsetspa
dc.subject.keywordAgedspa
dc.subject.keywordArthritiseng
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordFollow-up studiesspa
dc.subject.keywordFoot jointsspa
dc.subject.keywordHand jointsspa
dc.subject.keywordHla-dr antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordJointsspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPeptideseng
dc.subject.keywordProportional hazards modelsspa
dc.subject.keywordSex factorsspa
dc.subject.keywordSteroidsspa
dc.subject.keywordTime factorsspa
dc.subject.keywordTumor necrosis factor-alphaspa
dc.subject.keywordWrist jointspa
dc.subject.keywordAnti-ccp antibodiesspa
dc.subject.keywordExtra-articular manifestationsspa
dc.subject.keywordFamily relationsspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHla-drb1spa
dc.subject.keywordPolymorphismsspa
dc.subject.keywordRadiographyspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordTumor necrosis factorspa
dc.titleFamilial disease, the HLA-DRB1 shared epitope and anti-CCP antibodies influence time at appearance of substantial joint damage in rheumatoid arthritisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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