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Human papillomavirus detection in women with and without human immunodeficiency virus infection in Colombia

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dc.creatorCamargo, Milena
dc.creatorSoto-De Leon, Sara C
dc.creatorMunoz, Marina
dc.creatorSanchez, Ricardo
dc.creatorPeña-Herrera, Diego
dc.creatorPineda-Peña, Andrea Clemencia
dc.creatorSussmann, Otto
dc.creatorPaez, Carol
dc.creatorPerez-Prados, Antonio
dc.creatorPatarroyo, Manuel-Elkin
dc.creatorPatarroyo, Manuel A.
dc.creator.googleCamargo, Milenaspa
dc.creator.googleSoto-De Leon, Sara Cspa
dc.creator.googleMunoz, Marinaspa
dc.creator.googleSanchez, Ricardospa
dc.creator.googlePeña-Herrera, Diegospa
dc.creator.googlePineda-Peña, Andrea Clemenciaspa
dc.creator.googleSussmann, Ottospa
dc.creator.googlePaez, Carolspa
dc.creator.googlePerez-Prados, Antoniospa
dc.creator.googlePatarroyo, Manuel Elkinspa
dc.creator.googlePatarroyo, Manuel Alfonsospa
dc.date.accessioned2020-04-23T19:43:28Z
dc.date.available2020-04-23T19:43:28Z
dc.date.created2014
dc.date.issued2014
dc.description.abstractBackground: HIV infection leads to a decreasing immune response, thereby facilitating the appearance of other infections, one of the most important ones being HPV. However, studies are needed for determining associations between immunodeficiency caused by HIV and/or the presence of HPV during the course of cervical lesions and their degree of malignancy. This study describes the cytological findings revealed by the Papanicolaou test, laboratory characteristics and HPV molecular profile in women with and without HIV infection.Methods: A total of 216 HIV-positive and 1,159 HIV-negative women were invited to participate in the study; PCR was used for the molecular detection of HPV in cervical samples. Statistical analysis (such as percentages, Chi-square test and Fisher's exact test when applicable) determined human papillomavirus (HPV) infection frequency (single and multiple) and the distribution of six types of high-risk-HPV in women with and without HIV infection. Likewise, a logistic regression model was run to evaluate the relationship between HIV-HPV infection and different risk factors.Results: An association was found between the frequency of HPV infection and infection involving 2 or more HPV types (also known as multiple HPV infection) in HIV-positive women (69.0% and 54.2%, respectively); such frequency was greater than that found in HIV-negative women (44.3% and 22.7%, respectively). Statistically significant differences were observed between both groups (p = 0.001) regarding HPV presence (both in infection and multiple HPV infection). HPV-16 was the most prevalent type in the population being studied (p = 0.001); other viral types had variable distribution in both groups (HIV-positive and HIV-negative). HPV detection was associated with <500 cell/mm3 CD4-count (p = 0.004) and higher HIV-viral-load (p = 0.001). HPV-DNA detection, <200 cell/mm3 CD4-count (p = 0.001), and higher HIV-viral-load (p = 0.001) were associated with abnormal cytological findings.Conclusions: The HIV-1 positive population in this study had high multiple HPV infection prevalence. The results for this population group also suggested a greater association between HPV-DNA presence and cytological findings. HPV detection, together with low CD4 count, could represent useful tools for identifying HIV-positive women at risk of developing cervical lesions. © 2014 Camargo et al.; licensee BioMed Central Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/1471-2407-14-451
dc.identifier.issn1471-2407
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21754
dc.language.isoengspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleBMC Cancer
dc.relation.citationVolumeVol. 14
dc.relation.ispartofBMC Cancer, ISSN: 1471-2407 Vol. 14, No. 1 (2014)spa
dc.relation.urihttps://bmccancer.biomedcentral.com/track/pdf/10.1186/1471-2407-14-451spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcEnfermedadesspa
dc.subject.keywordEthnobotanyspa
dc.subject.keywordEthnobiologyspa
dc.subject.keywordLocal representationsspa
dc.subject.keywordConsumption preferencesspa
dc.subject.keywordFood plantsspa
dc.titleHuman papillomavirus detection in women with and without human immunodeficiency virus infection in Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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