Ítem
Solo Metadatos

Cost-Effectiveness Analysis of the Use of a Prophylactic Antibiotic for Patients Undergoing Lower Limb Amputation due to Diabetes or Vascular Illness in Colombia

Mostrar el registro sencillo de la publicación
dc.creatorCeballos M.spa
dc.creatorOrozco L.E.spa
dc.creatorValderrama C.O.spa
dc.creatorLondoño D.I.spa
dc.creatorLugo L.H.spa
dc.date.accessioned2020-05-25T23:56:42Z
dc.date.available2020-05-25T23:56:42Z
dc.date.created2017spa
dc.description.abstractBackground The use of a prophylactic antibiotic in an amputation surgery is a key element for the successful recovery of the patient. We aim to determine, from the perspective of the Colombian health system, the cost-effectiveness of administering a prophylactic antibiotic among patients undergoing lower limb amputation due to diabetes or vascular illness in Colombia. Methods A decision tree was constructed to compare the use and nonuse of a prophylactic antibiotic. The probabilities of transition were obtained from studies identified from a systematic review of the clinical literature. The chosen health outcome was reduction in mortality due to prevention of infection. The costs were measured by expert consensus using the standard case methodology, and the resource valuation was carried out using national-level pricing manuals. Deterministic sensitivity, scenarios, and probabilistic analyses were conducted. Results In the base case, the use of a prophylactic antibiotic compared with nonuse was a dominant strategy. This result was consistent when considering different types of medications and when modifying most of the variables in the model. The use of a prophylactic antibiotic ceases to be dominant when the probability of infection is greater than 48%. Conclusions The administration of a prophylactic antibiotic was a dominant strategy, which is a conclusion that holds in most cases examined; therefore, it is unlikely that the uncertainty around the estimation of costs and benefits change the results. We recommend creating policies oriented toward promoting the use of a prophylactic antibiotic during amputation surgery in Colombia. © 2016 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.avsg.2016.07.090
dc.identifier.issn16155947
dc.identifier.issn08905096
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22489
dc.language.isoengspa
dc.publisherElsevier Inc.spa
dc.relation.citationEndPage334
dc.relation.citationStartPage327
dc.relation.citationTitleAnnals of Vascular Surgery
dc.relation.citationVolumeVol. 40
dc.relation.ispartofAnnals of Vascular Surgery, ISSN:16155947, 08905096, Vol.40,(2017); pp. 327-334spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85010676975&doi=10.1016%2fj.avsg.2016.07.090&partnerID=40&md5=fbf113a52b70ce85ebb7eaadec93f1ecspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntibiotic agentspa
dc.subject.keywordeconomiceng
dc.subject.keywordCefazolinspa
dc.subject.keywordCefotaximespa
dc.subject.keywordCefoxitinspa
dc.subject.keywordCefuroximespa
dc.subject.keywordCephalosporinspa
dc.subject.keywordMeropenemspa
dc.subject.keywordPiperacillin plus tazobactamspa
dc.subject.keywordVancomycinspa
dc.subject.keywordAntiinfective agentspa
dc.subject.keywordAntibiotic prophylaxisspa
dc.subject.keywordBelow knee amputationspa
dc.subject.keywordColombiaspa
dc.subject.keywordComparative studyspa
dc.subject.keywordCost effectiveness analysisspa
dc.subject.keywordDeep infectionspa
dc.subject.keywordDiabetes mellitusspa
dc.subject.keywordDrug costspa
dc.subject.keywordDrug utilizationspa
dc.subject.keywordPostoperative infectionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordReviewspa
dc.subject.keywordSepsisspa
dc.subject.keywordSuperficial infectionspa
dc.subject.keywordSurgical mortalityspa
dc.subject.keywordSurgical patientspa
dc.subject.keywordVascular diseasespa
dc.subject.keywordAmputationspa
dc.subject.keywordAntibiotic prophylaxisspa
dc.subject.keywordCost benefit analysisspa
dc.subject.keywordDecision support systemspa
dc.subject.keywordDecision treespa
dc.subject.keywordDiabetic angiopathyspa
dc.subject.keywordDrug administrationspa
dc.subject.keywordEconomic modelspa
dc.subject.keywordEconomicsspa
dc.subject.keywordHumanspa
dc.subject.keywordLower limbspa
dc.subject.keywordMicrobiologyspa
dc.subject.keywordMortalityspa
dc.subject.keywordPeripheral vascular diseasespa
dc.subject.keywordSurgical infectionspa
dc.subject.keywordTreatment outcomespa
dc.subject.keywordVascularizationspa
dc.subject.keywordAmputationspa
dc.subject.keywordAnti-bacterial agentsspa
dc.subject.keywordAntibiotic prophylaxisspa
dc.subject.keywordColombiaspa
dc.subject.keywordCost-benefit analysisspa
dc.subject.keywordDecision support techniquesspa
dc.subject.keywordDecision treesspa
dc.subject.keywordDiabetic angiopathiesspa
dc.subject.keywordDrug administration schedulespa
dc.subject.keywordDrug costsspa
dc.subject.keywordHumansspa
dc.subject.keywordLower extremityspa
dc.subject.keywordModelseng
dc.subject.keywordPeripheral vascular diseasesspa
dc.subject.keywordSurgical wound infectionspa
dc.subject.keywordTreatment outcomespa
dc.titleCost-Effectiveness Analysis of the Use of a Prophylactic Antibiotic for Patients Undergoing Lower Limb Amputation due to Diabetes or Vascular Illness in Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos