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Estimating the intra-taxa diversity, population genetic structure, and evolutionary pathways of Cryptococcus neoformans and Cryptococcus gattii

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dc.contributor.gruplacGrupo de Investigaciones Microbiológicas - UR (GIMUR)spa
dc.creatorMuñoz, Marina
dc.creatorCamargo, Milena
dc.creatorRamírez, Juan David
dc.creator.googleMuñoz, Marina
dc.creator.googleCamargo, Milena
dc.creator.googleRamírez, Juan D.
dc.date.accessioned2019-09-26T19:53:13Z
dc.date.available2019-09-26T19:53:13Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractMembers of the Cryptococcus complex, includes Cryptococcus neoformans (most common fungal infection of the brain) and Cryptococcus gattii (high-impact emerging pathogen worldwide). Currently, the fungal multilocus sequence typing database (Fungal MLST Database) constitutes a valuable data repository of the genes used for molecular typing of these pathogens. We analyzed the data available in the Fungal MLST Database for seven housekeeping genes, with the aim to evaluate its contribution in the description of intra-taxa diversity, population genetic structure, and evolutionary patterns. Although the Fungal MLST Database has a greater number of reports for C. neoformans (n = 487) than for C. gattii (n = 344), similar results were obtained for both species in terms of allelic diversity. Phylogenetic reconstructions revealed grouping by molecular type in both species and allowed us to propose differences in evolutionary patterns (gradualism in the case of C. neoformans and punctuated evolution in the case of C. gattii). In addition, C. neoformans showed a population genetic structure consisting of 37 clonal complexes (CCs; CC1 being predominant), high crosslinking [without sequence type (ST) grouping by molecular type], marked divergence events in phylogenetic analysis, and few introgression events (mainly between VNI and VNIV). By contrast, C. gattii showed 50 CCs (with greater homogeneity in ST number by CC) and clustering by molecular type with marked crosslinking events in phylogenetic networks being less evident. Understanding relationships at the molecular level for species of the Cryptococcus complex, based on the sequences of the housekeeping genes, provides information for describing the evolutionary history of these emerging pathogens. © 2018 Muñoz, Camargo and Ramírez.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.3389/fgene.2018.00148
dc.identifier.issn1664-8021
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/20347
dc.language.isoengspa
dc.relation.citationTitleFrontiers in Genetics
dc.relation.citationVolumeVol. 9
dc.relation.ispartofFrontiers in Genetics, ISSN:1664-8021, Vol. 9 (2018)spa
dc.relation.urihttps://www.frontiersin.org/articles/10.3389/fgene.2018.00148/fullspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationAbassi, M., Boulware, D.R., Rhein, J., Cryptococcal meningitis: diagnosis and management update (2015) Curr. Trop. Med. Rep, 2, pp. 90-99spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectCross Linkingspa
dc.subjectCryptococcus Gattiispa
dc.subjectHousekeeping Genespa
dc.subjectHumanspa
dc.subjectInfectious Agentspa
dc.subjectIntrogressionspa
dc.subjectMajor Clinical Studyspa
dc.subjectMultilocus Sequence Typingspa
dc.subjectNonhumanspa
dc.subjectPhylogenyspa
dc.subjectPopulation Genetic Structurespa
dc.subjectReticulaciónspa
dc.subjectCryptococcus gattiispa
dc.subjectLa limpieza de genesspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordC. neoformansspa
dc.subject.keywordC. gattiispa
dc.subject.keywordMultilocus sequence typing (MLST)spa
dc.subject.keywordAllelic diversitspa
dc.subject.keywordPopulation structurespa
dc.subject.keywordEvolutionary historyspa
dc.subject.lembCriptococosisspa
dc.subject.lembMeningitis criptococoicaspa
dc.subject.lembMeningitis fúngicaspa
dc.titleEstimating the intra-taxa diversity, population genetic structure, and evolutionary pathways of Cryptococcus neoformans and Cryptococcus gattiispa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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