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Towards a poly-functional synthetic-antimalarial vaccine: Incorporating non-natural elements into artificially-made peptides for mimicking functional pathogen ligand structures representing new site-directed vaccine components

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dc.creatorLozano J.M.spa
dc.creatorPatarroyo M.E.spa
dc.date.accessioned2020-05-26T00:05:37Z
dc.date.available2020-05-26T00:05:37Z
dc.date.created2013spa
dc.description.abstractThe molecular basis for obtaining novel anti-malarial vaccine candidates depends on a considered selection of antigenic peptides, mainly derived from Plasmodium antigens' non-polymorphic regions. Since such targeted-molecules are poorly immunogenic when tested as vaccine components, they usually have to be modified to overcome their immunological phenotype. Transition state theory, explaining how peptidases catalyse a given peptide bond breakage, thus led to reduced amide pseudopeptides being proposed as possible mimetics for a transition-state. Stabilising such high-energy molecular stages could become a strategy for inducing antibodies potentially harbouring catalytic properties. Hence, isostere-bond peptido-mimetics represented a rational choice as potential abzyme-inducers and site-directed designed reduced amide pseudopeptides for obtaining peptide-analogues from selected malarial high-binding motifs. This novel family of vaccine candidates has proved to be an efficient functional antibody-inducer, the latter acting as efficient blockers of Plasmodium infection of human and mouse RBCs. © 2013 Bentham Science Publishers.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/1573395510666140401180738
dc.identifier.issn15733955
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23810
dc.language.isoengspa
dc.publisherBentham Science Publishers B.V.spa
dc.relation.citationEndPage275
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage261
dc.relation.citationTitleCurrent Immunology Reviews
dc.relation.citationVolumeVol. 9
dc.relation.ispartofCurrent Immunology Reviews, ISSN:15733955, Vol.9, No.4 (2013); pp. 261-275spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84900810092&doi=10.2174%2f1573395510666140401180738&partnerID=40&md5=1996fa48a6b02b66616178dfe32576b8spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmide pseudopeptidespa
dc.subject.keywordEpitopespa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordMerozoite surface protein 2spa
dc.subject.keywordParasite antibodyspa
dc.subject.keywordPeptide vaccinespa
dc.subject.keywordPeptidomimetic agentspa
dc.subject.keywordPseudopeptidespa
dc.subject.keywordSynthetic peptidespa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAntimalarial activityspa
dc.subject.keywordArticlespa
dc.subject.keywordErythrocytespa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordImmunoprophylaxisspa
dc.subject.keywordIn vitro studyspa
dc.subject.keywordMalariaspa
dc.subject.keywordMalaria falciparumspa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordPassive immunizationspa
dc.subject.keywordPhase transitionspa
dc.subject.keywordPlasmodium (life cycle stage)spa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtein hydrolysisspa
dc.subject.keywordProtein motifspa
dc.subject.keywordProtein targetingspa
dc.subject.keywordPublic health problemspa
dc.subject.keywordRodent malariaspa
dc.subject.keywordVaccine productionspa
dc.subject.keywordAntimalarial vaccinespa
dc.subject.keywordCatalytic antibodyspa
dc.subject.keywordPassive immunisationspa
dc.subject.keywordPeptide-bond isosterespa
dc.subject.keywordPeptido-mimeticspa
dc.subject.keywordPseudopeptidespa
dc.titleTowards a poly-functional synthetic-antimalarial vaccine: Incorporating non-natural elements into artificially-made peptides for mimicking functional pathogen ligand structures representing new site-directed vaccine componentsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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