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A TGF-? mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in children

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dc.creatorMesa, Martha C.spa
dc.creatorGutiérrez, Linaspa
dc.creatorDuarte-Rey, Carolina
dc.creatorAngel, Juanaspa
dc.creatorFranco, Manuel A.spa
dc.date.accessioned2020-08-19T14:44:15Z
dc.date.available2020-08-19T14:44:15Z
dc.date.created2010-03-30spa
dc.description.abstractChildren with acute RV-gastroenteritis (GE) had low or undetectable levels of circulating IFN-?+, IL-13+, IL-2+, IL-10+ or IL-17+ RV-T cells. IFN-?+ T cells and low frequencies of IL-10+ and IL-2+ CD4+ T cells were found in adults with RV-GE during acute and convalescence phases, respectively. Circulating single IFN-?+ > double IFN-?+/IL-2+ > single IL-2+RV-CD4+T cells were observed in healthy adults. In this group, frequencies of IFN-?+ RV-T cells increased after removing CD25+cells, blocking TGF-? with its natural inhibitor, LAP, or inhibiting TGF-?RI signalling pathway with ALK5i. The frequencies of IFN-?+ RV-T cells were also incremented in PBMC depleted of CD25+cells and treated with ALK5i, suggesting that TGF? inhibition may be independent of Treg cells. The ALK5i effect was observed in adults but not in children with RV-GE, who had normal numbers of TGF-?+ Treg cells. Thus, a TGF-?-mediated regulatory mechanism that modulates RV-T cells in adults is not evident in children.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.virol.2009.12.016
dc.identifier.issnISSN: 0042-6822
dc.identifier.issnEISSN: 1096-0341
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27853
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage86
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage77
dc.relation.citationTitleVirology
dc.relation.citationVolumeVol. 399
dc.relation.ispartofVirology, ISSN: 0042-6822;EISSN: 1096-0341, Vol.399, No.1 (2010); pp. 77-86spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0042682209008010spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceVirologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordRotavirusspa
dc.subject.keywordHumansspa
dc.subject.keywordInterferon-gammaspa
dc.subject.keywordInterleukin 13spa
dc.subject.keywordInterleukin-2spa
dc.subject.keywordInterleukin-10spa
dc.subject.keywordInterleukin-17spa
dc.subject.keywordTransforming growth factor betaT-lymphocytesspa
dc.subject.keywordT-lymphocytesspa
dc.subject.keywordregulatoryspa
dc.titleA TGF-? mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in childrenspa
dc.title.TranslatedTitleUn mecanismo regulador mediado por TGF-? modula la respuesta inmune de las células T al rotavirus en adultos pero no en niñosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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