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Immunization with hepatitis B vaccine accelerates SLE-like disease in a murine model

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dc.creatorAgmon-Levin, Nancyspa
dc.creatorArango, María-Teresaspa
dc.creatorKivity, Shayespa
dc.creatorKatzav, Avivaspa
dc.creatorGilburd, Borisspa
dc.creatorBlank, Mirispa
dc.creatorTomer, Nirspa
dc.creatorVolkov, Alexspa
dc.creatorBarshack, Irisspa
dc.creatorChapman, Joabspa
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-05-25T23:55:54Z
dc.date.available2020-05-25T23:55:54Z
dc.date.created2014spa
dc.description.abstractHepatitis-B vaccine (HBVv) can prevent HBV-infection and associated liver diseases. However, concerns regarding its safety, particularly among patients with autoimmune diseases (i.e. SLE) were raised. Moreover, the aluminum adjuvant in HBVv was related to immune mediated adverse events. Therefore, we examined the effects of immunization with HBVv or alum on SLE-like disease in a murine model.NZBWF1 mice were immunized with HBVv (Engerix), or aluminum hydroxide (alum) or phosphate buffered saline (PBS) at 8 and 12 weeks of age. Mice were followed for weight, autoantibodies titers, blood counts, proteinuria, kidney histology, neurocognitive functions (novel object recognition, staircase, Y-maze and the forced swimming tests) and brain histology.Immunization with HBVv induced acceleration of kidney disease manifested by high anti-dsDNA antibodies (. p less than 0.01), early onset of proteinuria (. p less than 0.05), histological damage and deposition of HBs antigen in the kidney. Mice immunized with HBVv and/or alum had decreased cells counts mainly of the red cell lineage (. p less than 0.001), memory deficits (. p less than 0.01), and increased activated microglia in different areas of the brain compare with mice immunized with PBS. Anxiety-like behavior was more pronounced among mice immunized with alum.In conclusion, herein we report that immunization with the HBVv aggravated kidney disease in an animal model of SLE. Immunization with either HBVv or alum affected blood counts, neurocognitive functions and brain gliosis. Our data support the concept that different component of vaccines may be linked with immune and autoimmune mediated adverse events. © 2014 Elsevier Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2014.06.006
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22257
dc.language.isoengspa
dc.publisherAcademic Pressspa
dc.relation.citationEndPage32
dc.relation.citationStartPage21
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 54
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.54,(2014); pp. 21-32spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84908495912&doi=10.1016%2fj.jaut.2014.06.006&partnerID=40&md5=2a3f8b48bb27518b4b8aafa4b2bb95b2spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAluminum hydroxidespa
dc.subject.keywordanimaleng
dc.subject.keywordHepatitis b surface antigenspa
dc.subject.keywordImmunological adjuvantspa
dc.subject.keywordPhosphate buffered salinespa
dc.subject.keywordRecombinant hepatitis b vaccinespa
dc.subject.keywordAntinuclear antibodyspa
dc.subject.keywordHepatitis b vaccinespa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAnimal tissuespa
dc.subject.keywordAntibody titerspa
dc.subject.keywordAnxietyspa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordBlood cell countspa
dc.subject.keywordBrain histologyspa
dc.subject.keywordBrain regionspa
dc.subject.keywordCell lineagespa
dc.subject.keywordCognitionspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease exacerbationspa
dc.subject.keywordDrug safetyspa
dc.subject.keywordErythrocytespa
dc.subject.keywordFemalespa
dc.subject.keywordForced swim testspa
dc.subject.keywordGliosisspa
dc.subject.keywordImmunizationspa
dc.subject.keywordKidney diseasespa
dc.subject.keywordLupus like syndromespa
dc.subject.keywordMemory disorderspa
dc.subject.keywordMicrogliaspa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordNovel object recognition testspa
dc.subject.keywordProteinuriaspa
dc.subject.keywordStaircase testspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordY-maze testspa
dc.subject.keywordAnimalspa
dc.subject.keywordBrainspa
dc.subject.keywordDisease modelspa
dc.subject.keywordDrug effectsspa
dc.subject.keywordImmunologyspa
dc.subject.keywordLupus erythematosus nephritisspa
dc.subject.keywordPathologyspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntibodieseng
dc.subject.keywordBrainspa
dc.subject.keywordCognitionspa
dc.subject.keywordDisease modelseng
dc.subject.keywordFemalespa
dc.subject.keywordHepatitis b vaccinesspa
dc.subject.keywordLupus nephritisspa
dc.subject.keywordMicespa
dc.subject.keywordProteinuriaspa
dc.subject.keywordAutoimmune/autoinflammatory syndrome induced by adjuvant (asia)spa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordHepatitis b vaccinespa
dc.subject.keywordNeuro-cognitive testsspa
dc.subject.keywordSlespa
dc.subject.keywordVaccinationspa
dc.titleImmunization with hepatitis B vaccine accelerates SLE-like disease in a murine modelspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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