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Polyautoimmunity and familial autoimmunity in systemic sclerosis

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dc.creatorHudson, Mariespa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorCoral-Alvarado, Paolaspa
dc.creatorLópez Guzmán, Silvia
dc.creatorMantilla, Ruben D.spa
dc.creatorChalem, Philippespa
dc.creatorGroup, Canadian Scleroderma Researchspa
dc.creatorGroup, Colombian Scleroderma Researchspa
dc.creatorBaron, Murrayspa
dc.creatorAnaya, Juan-Manuelspa
dc.creator.OrganizationalPan-American Collaborative Retina Study Group (PACORES)
dc.date.accessioned2020-05-25T23:55:52Z
dc.date.available2020-05-25T23:55:52Z
dc.date.created2008spa
dc.description.abstractCharacterization of the extent to which particular combinations of autoimmune diseases occur in excess of that expected by chance may offer new insights into possible common pathophysiological mechanisms. The goal of this study was to investigate the spectrum of polyautoimmunity (i.e. autoimmune diseases co-occurring within patients) and familial autoimmunity (i.e. diverse autoimmune diseases co-occurring within families) in patients with systemic sclerosis (SSc). A cross-sectional study of two convenience samples of patients with SSc, one in Canada and the other in Colombia, was performed. History of other autoimmune diseases in the SSc patients as well as a family history of autoimmunity was obtained. Of 719 patients, 273 (38%) had at least one other autoimmune disease. A total of 366 autoimmune diseases were reported, of which the most frequent were autoimmune thyroid disease (AITD, 38%), rheumatoid arthritis (RA, 21%), Sjögren's syndrome (18%), and primary biliary cirrhosis (4%). There were 260 (36%) patients with first-degree relatives with at least one autoimmune disease, of which the most frequent were RA (18%) and AITD (9%). Having at least one first-degree relative with autoimmune disease was a significant predictor of polyautoimmunity in SSc patients. No significant differences in polyautoimmunity or familial autoimmunity were noted between diffuse and limited subsets of disease. Our results indicate that polyautoimmunity is frequent in patients with SSc and autoimmune diseases cluster within families of these patients. Clinically different autoimmune phenotypes might share common susceptibility variants, which acting in epistatic pleiotropy may represent risk factors for autoimmunity. © 2008 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2008.05.002
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22248
dc.language.isoengspa
dc.relation.citationEndPage159
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage156
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 31
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.31, No.2 (2008); pp. 156-159spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-50549096136&doi=10.1016%2fj.jaut.2008.05.002&partnerID=40&md5=6f14e2ef457ed30cba0b999635a98523spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdultspa
dc.subject.keywordsystemiceng
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFamily historyspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordImmunityspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPhenotypespa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic sclerosisspa
dc.subject.keywordThyroid diseasespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCanadaspa
dc.subject.keywordColombiaspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPrevalencespa
dc.subject.keywordSclerodermaeng
dc.subject.keywordAutoimmune thyroid diseasespa
dc.subject.keywordFamilial autoimmunityspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordSystemic sclerosisspa
dc.titlePolyautoimmunity and familial autoimmunity in systemic sclerosisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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