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B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin

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dc.creatorCalderón Ospina, Carlos Alberto
dc.creatorNava Mesa, Mauricio Orlando
dc.date.accessioned2020-05-26T00:04:38Z
dc.date.available2020-05-26T00:04:38Z
dc.date.created2020spa
dc.description.abstractBackground: Neurotropic B vitamins play crucial roles as coenzymes and beyond in the nervous system. Particularly vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) contribute essentially to the maintenance of a healthy nervous system. Their importance is highlighted by many neurological diseases related to deficiencies in one or more of these vitamins, but they can improve certain neurological conditions even without a (proven) deficiency. Aim: This review focuses on the most important biochemical mechanisms, how they are linked with neurological functions and what deficits arise from malfunctioning of these pathways. Discussion: We discussed the main role of B Vitamins on several functions in the peripheral and central nervous system (PNS and CNS) including cellular energetic processes, antioxidative and neuroprotective effects, and both myelin and neurotransmitter synthesis. We also provide an overview of possible biochemical synergies between thiamine, pyridoxine, and cobalamin and discuss by which major roles each of them may contribute to the synergy and how these functions are inter-related and complement each other. Conclusion: Taking into account the current knowledge on the neurotropic vitamins B1, B6, and B12, we conclude that a biochemical synergy becomes apparent in many different pathways in the nervous system, particularly in the PNS as exemplified by their combined use in the treatment of peripheral neuropathy. © 2019 The Authors. CNS Neuroscience and Therapeutics published by John Wiley and Sons Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/cns.13207
dc.identifier.issn17555949
dc.identifier.issn17555930
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23700
dc.language.isoengspa
dc.publisherBlackwell Publishing Ltdspa
dc.relation.citationEndPage13
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage5
dc.relation.citationTitleCNS Neuroscience and Therapeutics
dc.relation.citationVolumeVol. 26
dc.relation.ispartofCNS Neuroscience and Therapeutics, ISSN:17555949, 17555930, Vol.26, No.1 (2020); pp. 5-13spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071838898&doi=10.1111%2fcns.13207&partnerID=40&md5=2e15e55939cf58f1251e90f5b62bea35spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCobalaminspa
dc.subject.keywordMyelinspa
dc.subject.keywordNeurotransmitterspa
dc.subject.keywordPyridoxinespa
dc.subject.keywordThiaminespa
dc.subject.keywordVitamin b groupspa
dc.subject.keywordAntioxidant activityspa
dc.subject.keywordBiochemical analysisspa
dc.subject.keywordBlood brain barrierspa
dc.subject.keywordBrain developmentspa
dc.subject.keywordBrain regionspa
dc.subject.keywordCell energyspa
dc.subject.keywordCentral nervous system functionspa
dc.subject.keywordCitric acid cyclespa
dc.subject.keywordDisease associationspa
dc.subject.keywordGestation periodspa
dc.subject.keywordGlucose metabolismspa
dc.subject.keywordGlycolysisspa
dc.subject.keywordHumanspa
dc.subject.keywordNerve stimulationspa
dc.subject.keywordNervous systemspa
dc.subject.keywordNeuromodulationspa
dc.subject.keywordNeuroprotectionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPentose phosphate cyclespa
dc.subject.keywordPeripheral nervous system functionspa
dc.subject.keywordPernicious anemiaspa
dc.subject.keywordProtein synthesisspa
dc.subject.keywordReviewspa
dc.subject.keywordSignal transductionspa
dc.subject.keywordSynaptic transmissionspa
dc.subject.keywordThiamine deficiencyspa
dc.subject.keywordVitamin intakespa
dc.subject.keywordB vitaminsspa
dc.subject.keywordBiochemical action mechanismspa
dc.subject.keywordNeuropathyspa
dc.subject.keywordPyridoxinespa
dc.subject.keywordThiaminespa
dc.subject.keywordVitamin b12spa
dc.titleB Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalaminspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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