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T265. Fluctuations in craving and mood state bias subjective valuation in addiction

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dc.creatorMessinger, Johnspa
dc.creatorLopez-Guzman, Silviaspa
dc.creatorBanavar, Nidhispa
dc.creatorRotrosen, Johnspa
dc.creatorGlimcher, Paulspa
dc.creatorKonova, Annaspa
dc.date.accessioned2020-08-06T16:20:03Z
dc.date.available2020-08-06T16:20:03Z
dc.date.created2018-05-01spa
dc.description.abstractBackground How craving and mood states (e.g., stress, boredom) bias behavior toward rewarding but less adaptive alternatives and away from an individual’s health goals is poorly understood, yet play a critical role in addiction and eating disorders. Here we test the hypothesis that underlying this bias is a state-dependent increase in the subjective value of these rewarding but less-adaptive choice alternatives. Methods 27 treatment-seeking opioid users completed a decision-making task that probed their momentary willingness-to-pay for a range of real opioid use–related and –unrelated goods, a quantitative measure of their value. These goods were identified as most (least) related to an individual subject's use. To capture how dynamics in spontaneous opioid craving and mood affect subjective valuation, patients completed the task over 2 days while continuously reporting their current opioid craving, stress level, boredom, and happiness. Skin conductance and facial EMG were measured concurrently as indices of arousal and valence, respectively. Results Subjects were willing to pay more specifically for personalized opioid-related goods when experiencing higher craving, stress, and boredom and lower happiness (subjective state level X opioid-relatedness: P<0.016). Despite mild correlation across subjective states (R=0.14–0.51), the effects of each on valuation were largely independent, particularly of craving and stress. Analysis of physiological data is ongoing, but we hypothesize these data will serve as auxiliary, objective measures of how subjective states bias valuation. Conclusions These data suggest craving and stress both enhance the value of less-adaptive choice alternatives when these are immediately rewarding, potentially reflecting a compensatory mechanism aimed at buffering these states.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.biopsych.2018.02.602
dc.identifier.issnISSN: 0006-3223
dc.identifier.issnEISSN: 1873-2402
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25866
dc.language.isoengspa
dc.publisherSociety of Biological Psychiatryspa
dc.publisherElsevierspa
dc.relation.citationEndPageS233
dc.relation.citationIssueNo. 9 Supplement
dc.relation.citationStartPageS232
dc.relation.citationTitleBiological Psychiatry
dc.relation.citationVolumeVol. 83
dc.relation.ispartofBiological Psychiatry, ISSN: 0006-3223;EISSN: 1873-2402, Vol.83 No.9 Supplement (2018); pp.S232-S233spa
dc.relation.urihttps://www.biologicalpsychiatryjournal.com/article/S0006-3223(18)30704-2/pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceBiological Psychiatryspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordCravingspa
dc.subject.keywordStressspa
dc.subject.keywordDecision-makingspa
dc.subject.keywordSubjective valuespa
dc.subject.keywordOpioid addictionspa
dc.titleT265. Fluctuations in craving and mood state bias subjective valuation in addictioneng
dc.title.TranslatedTitleT265. Fluctuaciones en el antojo y el estado de ánimo sesgo valoración subjetiva en adicciónspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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