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Neuroimmunomodulation in Major Depressive Disorder: Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma

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dc.creatorInserra, Antoniospa
dc.creatorMastronardi, Claudio Albertospa
dc.creatorRogers, Geraintspa
dc.creatorLicinio, Juliospa
dc.creatorWong, Ma-Lispa
dc.date.accessioned2020-05-25T23:57:10Z
dc.date.available2020-05-25T23:57:10Z
dc.date.created2019spa
dc.description.abstractMajor depressive disorder (MDD) is one of the leading causes of disability worldwide, and its incidence is expected to increase. Despite tremendous efforts to understand its underlying biological mechanisms, MDD pathophysiology remains elusive and pharmacotherapy outcomes are still far from ideal. Low-grade chronic inflammation seems to play a key role in mediating the interface between psychological stress, depressive symptomatology, altered intestinal microbiology, and MDD onset. We review the available pre-clinical and clinical evidence of an involvement of pro-inflammatory pathways in the pathogenesis, treatment, and remission of MDD. We focus on caspase 1, inducible nitric oxide synthase, and interferon gamma, three inflammatory systems dysregulated in MDD. Treatment strategies aiming at targeting such pathways alone or in combination with classical therapies could prove valuable in MDD. Further studies are needed to assess the safety and efficacy of immune modulation in MDD and other psychiatric disorders with neuroinflammatory components. © 2018, The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s12035-018-1359-3
dc.identifier.issn8937648
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22620
dc.language.isoengspa
dc.publisherHumana Press Inc.spa
dc.relation.citationEndPage4305
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage4288
dc.relation.citationTitleMolecular Neurobiology
dc.relation.citationVolumeVol. 56
dc.relation.ispartofMolecular Neurobiology, ISSN:8937648, Vol.56, No.6 (2019); pp. 4288-4305spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85055265512&doi=10.1007%2fs12035-018-1359-3&partnerID=40&md5=1a9c9ba38fda94df760c24462067e52espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmfebutamonespa
dc.subject.keywordmajoreng
dc.subject.keywordBrain derived neurotrophic factorspa
dc.subject.keywordCytokinespa
dc.subject.keywordGamma interferonspa
dc.subject.keywordGlucocorticoidspa
dc.subject.keywordInducible nitric oxide synthasespa
dc.subject.keywordInterleukin 18spa
dc.subject.keywordInterleukin 1alphaspa
dc.subject.keywordInterleukin 1betaspa
dc.subject.keywordInterleukin 1beta converting enzymespa
dc.subject.keywordInterleukin 33spa
dc.subject.keywordMemantinespa
dc.subject.keywordNeurotransmitterspa
dc.subject.keywordReactive oxygen metabolitespa
dc.subject.keywordVenlafaxinespa
dc.subject.keywordGamma interferonspa
dc.subject.keywordInducible nitric oxide synthasespa
dc.subject.keywordInterleukin 1beta converting enzymespa
dc.subject.keywordAntidepressant activityspa
dc.subject.keywordClinical studyspa
dc.subject.keywordCytokine productionspa
dc.subject.keywordCytokine responsespa
dc.subject.keywordDrug efficacyspa
dc.subject.keywordDrug safetyspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunomodulationspa
dc.subject.keywordInnate immunityspa
dc.subject.keywordIntestine floraspa
dc.subject.keywordIntracellular signalingspa
dc.subject.keywordMajor depressionspa
dc.subject.keywordMental diseasespa
dc.subject.keywordNervous system inflammationspa
dc.subject.keywordNeuropathologyspa
dc.subject.keywordNitrosative stressspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPreclinical studyspa
dc.subject.keywordProtein synthesis inhibitionspa
dc.subject.keywordRemissionspa
dc.subject.keywordReviewspa
dc.subject.keywordAnimalspa
dc.subject.keywordEnzymologyspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMajor depressionspa
dc.subject.keywordMetabolismspa
dc.subject.keywordMicrobiologyspa
dc.subject.keywordAnimalsspa
dc.subject.keywordCaspase 1spa
dc.subject.keywordDepressive disordereng
dc.subject.keywordGastrointestinal microbiomespa
dc.subject.keywordHumansspa
dc.subject.keywordInterferon-gammaspa
dc.subject.keywordNeuroimmunomodulationspa
dc.subject.keywordNitric oxide synthase type iispa
dc.subject.keywordCaspase 1spa
dc.subject.keywordGut microbiomespa
dc.subject.keywordInducible nitric oxide synthasespa
dc.subject.keywordInflammasomespa
dc.subject.keywordInflammationspa
dc.subject.keywordInterferon gammaspa
dc.subject.keywordInterleukin 1spa
dc.subject.keywordMajor depressive disorderspa
dc.subject.keywordMddspa
dc.subject.keywordNeuroinflammationspa
dc.subject.keywordT-helper 1 (th1)spa
dc.titleNeuroimmunomodulation in Major Depressive Disorder: Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gammaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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