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GDF15(MIC1) H6D Polymorphism does not influence cardiovascular disease in a Latin American population with Rheumatoid Arthritis

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dc.creatorAmaya-Amaya, Jenny
dc.creatorRojas-Villarraga, Adriana
dc.creatorMolano González, Nicolás
dc.creatorMontoya-Sánchez, Laura
dc.creatorNath, Swapan K.
dc.creatorAnaya, Juan-Manuel
dc.creator.googleAmaya-Amaya, Jennyspa
dc.creator.googleRojas-Villarraga, Adrianaspa
dc.creator.googleMolano-Gonzalez, Nicolasspa
dc.creator.googleMontoya-Sánchez, Lauraspa
dc.creator.googleNath, Swapan K.spa
dc.creator.googleAnaya, Juna-Manuelspa
dc.date.accessioned2020-04-11T18:07:56Z
dc.date.available2020-04-11T18:07:56Z
dc.date.created2015
dc.date.issued2015
dc.description.abstractObjective. Rheumatoid arthritis (RA) is the most common autoimmune arthropathy worldwide. The increased prevalence of cardiovascular disease (CVD) in RA is not fully explained by classic risk factors. The aim of this study was to determine the influence of rs1058587 SNP within GDF15(MIC1) gene on the risk of CVD in a Colombian RA population. Methods. This was a cross-sectional analytical study in which 310 consecutive Colombian patients with RA and 228 age- and sex-matched controls were included and assessed for variables associated with CVD. The mixed cluster methodology based on multivariate descriptive methods such as principal components analysis and multiple correspondence analyses and regression tree (CART) predictive model were performed. Results. Of the 310 patients, 87.4% were women and CVD was reported in 69.5%. Significant differences concerning GDF15 polymorphism were not observed between patients and controls. Mean arterial pressure, current smoking, and some clusters were significantly associated with CVD. Conclusion. GDF15 (rs1058587) does not influence the development of CVD in the population studied. Copyright © 2015 Jenny Amaya-Amaya et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2015/270763
dc.identifier.issn2314-8861
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21536
dc.language.isoengspa
dc.relation.citationTitleJournal of Immunology Research
dc.relation.citationVolumeVol. 2015
dc.relation.ispartofJournal of Immunology Research, ISSN: 2314-8861 Vol. 2015, (2015)spa
dc.relation.urihttps://www.hindawi.com/journals/jir/2015/270763/spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcEnfermedadesspa
dc.subject.keywordAbataceptspa
dc.subject.keywordAdalimumabspa
dc.subject.keywordAntinuclear antibodyspa
dc.subject.keywordAzathioprinespa
dc.subject.keywordChloroquinespa
dc.subject.keywordCyclosporinspa
dc.subject.keywordDeflazacortspa
dc.subject.keywordEtanerceptspa
dc.subject.keywordGenomic DNAspa
dc.subject.keywordGold saltspa
dc.subject.keywordGrowth differentiation factor 15spa
dc.subject.keywordHydroxychloroquinespa
dc.subject.keywordInfliximabspa
dc.subject.keywordLeflunomidespa
dc.subject.keywordMethotrexatespa
dc.subject.keywordMethylprednisolonespa
dc.subject.keywordPenicillaminespa
dc.subject.keywordPrednisolonespa
dc.subject.keywordRheumatoid factorspa
dc.subject.keywordFactor reumatoidespa
dc.subject.keywordADN genómicospa
dc.subject.keywordArtritis reumatoidespa
dc.subject.lembEnfermedades cardiovascularesspa
dc.subject.lembArtritis reumatoidespa
dc.titleGDF15(MIC1) H6D Polymorphism does not influence cardiovascular disease in a Latin American population with Rheumatoid Arthritisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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