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Immunogenicity of Hepavax-Gene recombinant hepatitis B vaccine in INML workers, Colombia

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dc.creatorSiachoque H.spa
dc.creatorIbáñez Pinilla, Milcíadesspa
dc.date.accessioned2020-05-26T00:04:48Z
dc.date.available2020-05-26T00:04:48Z
dc.date.created2007spa
dc.description.abstractObjective: To evaluate the immunogenicity of Hepavax-Gene recombinant hepatitis B vaccine in INML workers since the last administered doses. Methods: Cross-sectional study on 603 health workers with at least three administered recombinant vaccine doses. Antibody levels (anti-HBs) were measured using the ELISA technique during December 2000 and January 2001, taking into account that the last dose in the vaccination varied between 1 and 6 years. Results: A total of 344 men and 259 women with an age mean of 38.8±7.3 years were studied. Protection levels were found in 90.7% (?10 U/1), decreasing significantly with the worker's age (p less than 0.00 1) and with the vaccine last dose administration time (p less than 0.01). Health workers with four doses compared to those with three doses had a 4.7% higher protection (antibody median 209.8 vs. 130.07, p less than 0.001). No association was found with gender (p=0.463), smoking (p=0.331) and blood exposure (p=0.433). Multivariate analyses found that no protection associated only with age (40-44 years HR=2.37, Cl 95%:1.18,4.78 and ?45 years HR=3.58, Cl 95%: 1.83,6.99). Conclusions: Although Hepavax-Gene recombinant hepatitis B vaccine (anti-HBs) has a high effectiveness in the health workers (90.7%) it presents a decrease in protection levels related to a higher worker's age and along vaccine last dose administration time. © 2007 Corporación Editora Médica del Valle.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn16579534
dc.identifier.issn01208322
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23720
dc.language.isoengspa
dc.publisherUniversidad del Valle-Facultad de Saludspa
dc.relation.citationEndPage381
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage375
dc.relation.citationTitleColombia Medica
dc.relation.citationVolumeVol. 38
dc.relation.ispartofColombia Medica, ISSN:16579534, 01208322, Vol.38, No.4 (2007); pp. 375-381spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-38349068912&partnerID=40&md5=4aa33def3e6d4a2d6537b38eb73ce849spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHepatitis B antibodyspa
dc.subject.keywordHepavaxspa
dc.subject.keywordRecombinant hepatitis B vaccinespa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAdultspa
dc.subject.keywordAge distributionspa
dc.subject.keywordArticlespa
dc.subject.keywordCigarette smokingspa
dc.subject.keywordColombiaspa
dc.subject.keywordDose time effect relationspa
dc.subject.keywordDrug dose comparisonspa
dc.subject.keywordDrug efficacyspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordFemalespa
dc.subject.keywordHealth care personnelspa
dc.subject.keywordHepatitis Bspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMultivariate analysisspa
dc.subject.keywordOccupational healthspa
dc.subject.keywordPrevalencespa
dc.subject.keywordSex differencespa
dc.subject.keywordHepatitis Bspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordVaccinationspa
dc.titleImmunogenicity of Hepavax-Gene recombinant hepatitis B vaccine in INML workers, Colombiaspa
dc.title.TranslatedTitleImmunogenicidad de una vacuna recombinante anti-HBs en trabajadores de la salud, del instituto de Medicina Legal de Colombiaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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