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HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier : A densely sampled transmission dynamics analysis from 1986 to 2012

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dc.creatorPineda-Peña, Andrea-Clemencia
dc.creatorTheys, Kristof
dc.creatorStylianou, Dora C.
dc.creatorDemetriades, Ioannis
dc.creatorPuchhammer, Elisabeth
dc.creatorVandamme, Anne-Mieke
dc.creatorAleksiev, Ivailo
dc.creatorZidovec Lepej, Snjezana
dc.creatorLinka, Marek
dc.creatorFonage, Jannik
dc.creatorLiitsola, Kirsi
dc.creatorKaiser, Rolf
dc.creatorHamouda, Osamah
dc.creatorParaskevis, Dimitrios
dc.creatorCoughlan, Suzie
dc.creatorGrossman, Zehava
dc.creatorMor, Orna
dc.creatorZazzi, Maurizio
dc.creatorGriskevicius, Algirdas
dc.creatorLipnickiene, Vilnele
dc.creatorDevaux, Carole
dc.creatorBoucher, Charles
dc.creatorHofstra, Marije
dc.creatorWensing, Annemarie
dc.creatorBakken-Kran, Anne-Marte
dc.creatorHorban, Andrzej
dc.creatorCamacho, Ricardo
dc.creatorParaschiv, Simona
dc.creatorOtelea, Dan
dc.creatorStanojevic, Maja
dc.creatorStanekova, Danika
dc.creatorPoljak, Mario
dc.creatorGarcia, Federico
dc.creatorParedes, Roger
dc.creatorAlbert, Jan
dc.creatorAbecasis, Ana
dc.creatorKostrikis, Leondios G.
dc.creator.googlePineda-Peña, A.-C.spa
dc.creator.googleTheys, K.spa
dc.creator.googleStylianou, D.C.spa
dc.creator.googleDemetriades, I.spa
dc.creator.googlePuchhammer, E.spa
dc.creator.googleVandamme, A.-M.spa
dc.creator.googleAleksiev, I.spa
dc.creator.googleLepej, S.Z.spa
dc.creator.googleLinka, M.spa
dc.creator.googleFonager, J.spa
dc.creator.googleLiitsola, K.spa
dc.creator.googleKaiser, R.spa
dc.creator.googleHamouda, O.spa
dc.creator.googleParaskevis, D.spa
dc.creator.googleCoughlan, S.spa
dc.creator.googleGrossman, Z.spa
dc.creator.googleMor, O.spa
dc.creator.googleZazzi, M.spa
dc.creator.googleGriskevicius, A.spa
dc.creator.googleLipnickiene, V.spa
dc.creator.googleDevaux, C.spa
dc.creator.googleBoucher, C.spa
dc.creator.googleHofstra, M.spa
dc.creator.googleWensing, A.spa
dc.creator.googleBakken-Kran, A.-M.spa
dc.creator.googleHorban, A.spa
dc.creator.googleCamacho, R.spa
dc.creator.googleParaschiv, S.spa
dc.creator.googleOtelea, D.spa
dc.creator.googleStanojevic, M.spa
dc.creator.googleStanekova, D.spa
dc.creator.googlePoljak, M.spa
dc.creator.googleGarcia, F.spa
dc.creator.googleParedes, R.spa
dc.creator.googleAlbert, J.spa
dc.creator.googleAbecasis, A.B.spa
dc.creator.googleKostrikis, L.G.spa
dc.date.accessioned2019-10-03T13:38:20Z
dc.date.available2019-10-03T13:38:20Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractSince HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings. © 2018 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.1038/s41598-017-19080-5
dc.identifier.issn2045-2322
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/20385
dc.language.isoengspa
dc.relation.citationTitleScientific Reports
dc.relation.citationVolumeVol. 8
dc.relation.ispartofScientific Reports, ISSN:2045-2322, Vol. 8 (2018)spa
dc.relation.urihttps://www.nature.com/articles/s41598-017-19080-5spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitation(2016) Joint United Nations Programme on HIV/AIDS, , United Nations Programme on HIV/AIDS-UNAIDS-. Fact Sheet 2017: Global Statistics 2016, Geneva, Switzerlandspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectInfection Cyprusspa
dc.subjectOfhivinfected Individualsspa
dc.subject.ddcEnfermedadesspa
dc.subject.lembVIHspa
dc.subject.lembSíndromes de inmunodeficienciaspa
dc.subject.lembSidaspa
dc.titleHIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier : A densely sampled transmission dynamics analysis from 1986 to 2012spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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