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ADGRL3 (LPHN3) variants predict substance use disorder

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dc.creatorArcos-Burgos, Mauricio
dc.creatorVélez, Jorge I.spa
dc.creatorMartinez, Ariel F.spa
dc.creatorRibasés, Martaspa
dc.creatorRamos-Quiroga, Josep A.spa
dc.creatorSánchez-Mora, Cristinaspa
dc.creatorRicharte, Vanesaspa
dc.creatorRoncero, Carlosspa
dc.creatorCormand, Bruspa
dc.creatorFernández-Castillo, Noeliaspa
dc.creatorCasas, Miguelspa
dc.creatorLopera, Franciscospa
dc.creatorPineda, David A.spa
dc.creatorPalacio, Juan D.spa
dc.creatorAcosta-López, Johan E.spa
dc.creatorCervantes-Henriquez, Martha L.spa
dc.creatorSánchez-Rojas, Manuel G.spa
dc.creatorPuentes-Rozo, Pedro J.spa
dc.creatorMolina, Brooke S. G.spa
dc.creatorBoden, Margaret T.spa
dc.creatorWallis, Deeannspa
dc.creatorLidbury, Brettspa
dc.creatorNewman, Saulspa
dc.creatorEasteal, Simonspa
dc.creatorSwanson, Jamesspa
dc.creatorPatel, Hardipspa
dc.creatorVolkow, Noraspa
dc.creatorAcosta, Maria T.spa
dc.creatorCastellanos, Francisco X.spa
dc.creatorde Leon, Josespa
dc.creatorMastronardi, Claudio A.spa
dc.creatorMuenke, Maximilianspa
dc.date.accessioned2020-05-26T00:01:37Z
dc.date.available2020-05-26T00:01:37Z
dc.date.created2019spa
dc.description.abstractGenetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use disorder (SUD). Variants in the ADGRL3 (LPHN3) gene predispose to ADHD and predict ADHD severity, disruptive behaviors comorbidity, long-term outcome, and response to treatment. In this study, we investigated whether variants within ADGRL3 are associated with SUD, a disorder that is frequently co-morbid with ADHD. Using family-based, case-control, and longitudinal samples from disparate regions of the world (n = 2698), recruited either for clinical, genetic epidemiological or pharmacogenomic studies of ADHD, we assembled recursive-partitioning frameworks (classification tree analyses) with clinical, demographic, and ADGRL3 genetic information to predict SUD susceptibility. Our results indicate that SUD can be efficiently and robustly predicted in ADHD participants. The genetic models used remained highly efficient in predicting SUD in a large sample of individuals with severe SUD from a psychiatric institution that were not ascertained on the basis of ADHD diagnosis, thus identifying ADGRL3 as a risk gene for SUD. Recursive-partitioning analyses revealed that rs4860437 was the predominant predictive variant. This new methodological approach offers novel insights into higher order predictive interactions and offers a unique opportunity for translational application in the clinical assessment of patients at high risk for SUD. © 2019, The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/s41398-019-0396-7
dc.identifier.issn21583188
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23388
dc.language.isoengspa
dc.publisherNature Publishing Groupspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleTranslational Psychiatry
dc.relation.citationVolumeVol. 9
dc.relation.ispartofTranslational Psychiatry, ISSN:21583188, Vol.9, No.1 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060775449&doi=10.1038%2fs41398-019-0396-7&partnerID=40&md5=23868d5b50154cfc251fa8075292a9b6spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdhesion g protein coupled receptor l3spa
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordBarbituric acid derivativespa
dc.subject.keywordCocainespa
dc.subject.keywordG protein coupled receptorspa
dc.subject.keywordGenomic dnaspa
dc.subject.keywordOpiatespa
dc.subject.keywordPsychedelic agentspa
dc.subject.keywordSedative agentspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordG protein coupled receptorspa
dc.subject.keywordLphn3 proteineng
dc.subject.keywordReceptorspa
dc.subject.keywordAdhesion g protein coupled receptor l3 genespa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAlcoholismspa
dc.subject.keywordArticlespa
dc.subject.keywordAttention deficit disorderspa
dc.subject.keywordCannabis addictionspa
dc.subject.keywordChildspa
dc.subject.keywordClinical assessmentspa
dc.subject.keywordCohort analysisspa
dc.subject.keywordComorbidityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDemographyspa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordFamilyspa
dc.subject.keywordFemalespa
dc.subject.keywordGenespa
dc.subject.keywordGene locusspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic epidemiologyspa
dc.subject.keywordGenetic modelspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHumanspa
dc.subject.keywordLongitudinal studyspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPharmacogenetic testingspa
dc.subject.keywordPopulation based case control studyspa
dc.subject.keywordPredictionspa
dc.subject.keywordRandomized controlled trialspa
dc.subject.keywordRetrospective studyspa
dc.subject.keywordTobacco dependencespa
dc.subject.keywordCase control studyspa
dc.subject.keywordDrug dependencespa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordYoung adultspa
dc.subject.keywordAdultspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHumansspa
dc.subject.keywordLongitudinal studiesspa
dc.subject.keywordMalespa
dc.subject.keywordPolymorphismeng
dc.subject.keywordReceptorseng
dc.subject.keywordReceptorseng
dc.subject.keywordRisk factorsspa
dc.subject.keywordSubstance-related disordersspa
dc.subject.keywordYoung adultspa
dc.titleADGRL3 (LPHN3) variants predict substance use disorderspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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