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Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil

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dc.creatorInbar R.spa
dc.creatorWeiss R.spa
dc.creatorTomljenovic L.spa
dc.creatorArango M.-T.spa
dc.creatorDeri Y.spa
dc.creatorShaw C.A.spa
dc.creatorChapman J.spa
dc.creatorBlank M.spa
dc.creatorShoenfeld Y.spa
dc.date.accessioned2020-05-26T00:11:03Z
dc.date.available2020-05-26T00:11:03Z
dc.date.created2017spa
dc.description.abstractVaccine adjuvants and vaccines may induce autoimmune and inflammatory manifestations in susceptible individuals. To date most human vaccine trials utilize aluminum (Al) adjuvants as placebos despite much evidence showing that Al in vaccine-relevant exposures can be toxic to humans and animals. We sought to evaluate the effects of Al adjuvant and the HPV vaccine Gardasil versus the true placebo on behavioral and inflammatory parameters in female mice. Six-week-old C57BL/6 female mice were injected with either, Gardasil, Gardasil + pertussis toxin (Pt), Al hydroxide, or, vehicle control in amounts equivalent to human exposure. At 7.5 months of age, Gardasil and Al-injected mice spent significantly more time floating in the forced swimming test (FST) in comparison with vehicle-injected mice (Al, p = 0.009; Gardasil, p = 0.025; Gardasil + Pt, p = 0.005). The increase in floating time was already highly significant at 4.5 months of age for the Gardasil and Gardasil + Pt group (p ? 0.0001). No significant differences were observed in the number of stairs climbed in the staircase test which measures locomotor activity. These results indicate that differences observed in the FST were unlikely due to locomotor dysfunction, but rather due to depression. Moreover, anti-HPV antibodies from the sera of Gardasil and Gardasil + Pt-injected mice showed cross-reactivity with the mouse brain protein extract. Immunohistochemistry analysis revealed microglial activation in the CA1 area of the hippocampus of Gardasil-injected mice. It appears that Gardasil via its Al adjuvant and HPV antigens has the ability to trigger neuroinflammation and autoimmune reactions, further leading to behavioral changes. © 2016, Springer Science+Business Media New York.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s12026-016-8826-6
dc.identifier.issn0257277X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24278
dc.language.isoengspa
dc.publisherHumana Press Inc.spa
dc.relation.citationEndPage149
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage136
dc.relation.citationTitleImmunologic Research
dc.relation.citationVolumeVol. 65
dc.relation.ispartofImmunologic Research, ISSN:0257277X, Vol.65, No.1 (2017); pp. 136-149spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84978818868&doi=10.1007%2fs12026-016-8826-6&partnerID=40&md5=d83cebc35d79ab730bbad9833506b010spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAluminum hydroxidespa
dc.subject.keywordhuman papillomaviruseng
dc.subject.keywordPertussis toxinspa
dc.subject.keywordWart virus vaccinespa
dc.subject.keywordAluminum hydroxidespa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordCapsid proteinspa
dc.subject.keywordHpv l1 proteineng
dc.subject.keywordImmunological adjuvantspa
dc.subject.keywordOncoproteinspa
dc.subject.keywordPharmaceutical vehicles and additivesspa
dc.subject.keywordVirus antibodyspa
dc.subject.keywordVirus antigenspa
dc.subject.keywordWart virus vaccinespa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAnimal tissuespa
dc.subject.keywordArticlespa
dc.subject.keywordBehavior disorderspa
dc.subject.keywordBrain perfusionspa
dc.subject.keywordCognitionspa
dc.subject.keywordControlled studyspa
dc.subject.keywordEnzyme inhibition assayspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordFemalespa
dc.subject.keywordForced swim testspa
dc.subject.keywordHippocampusspa
dc.subject.keywordImmunohistochemistryspa
dc.subject.keywordLocomotionspa
dc.subject.keywordMicrogliaspa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordStaircase testspa
dc.subject.keywordVisual memoryspa
dc.subject.keywordAnimalspa
dc.subject.keywordAnimal behaviorspa
dc.subject.keywordBloodspa
dc.subject.keywordC57bl mousespa
dc.subject.keywordDrug effectsspa
dc.subject.keywordImmunologyspa
dc.subject.keywordRecognitionspa
dc.subject.keywordSwimmingspa
dc.subject.keywordAdjuvantseng
dc.subject.keywordAdjuvantseng
dc.subject.keywordAluminum hydroxidespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntibodieseng
dc.subject.keywordAntigenseng
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordBehavioreng
dc.subject.keywordCapsid proteinsspa
dc.subject.keywordFemalespa
dc.subject.keywordHuman papillomavirus recombinant vaccine quadrivalent, types 6, 11, 16, 18spa
dc.subject.keywordLocomotionspa
dc.subject.keywordMiceeng
dc.subject.keywordOncogene proteinseng
dc.subject.keywordRecognition (psychology)spa
dc.subject.keywordSwimmingspa
dc.subject.keywordAluminumspa
dc.subject.keywordAsia syndromespa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGardasilspa
dc.subject.keywordNeuroinflammationspa
dc.titleBehavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasilspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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