Ítem
Acceso Abierto

Quantification of cell-free DNA for evaluating genotoxic damage from occupational exposure to car paints

Mostrar el registro sencillo de la publicación
dc.creatorVillalba-Campos, Mónica
dc.creatorRamírez Clavijo, Sandra Rocío
dc.creatorSanchez-Corredor, Magda-Carolina
dc.creatorRondón Lagos, Milena
dc.creatorIbáñez Pinilla, Milcíades
dc.creatorPalma, Ruth Marien
dc.creatorVarona Uribe, Marcela Eugenia
dc.creatorChuaire-Noack, Lilian
dc.creator.googleVillalba-Campos, M.spa
dc.creator.googleRamírez-Clavijo, Sandra Rocíospa
dc.creator.googleSánchez-Corredor, Magda Carolinaspa
dc.creator.googleRondón-Lagos, M.spa
dc.creator.googleIbáñez-Pinilla, M.spa
dc.creator.googlePalma, Ruth Marienspa
dc.creator.googleVarona-Uribe, Marcela Eugeniaspa
dc.creator.googleChuaire-Noack, L.spa
dc.date.accessioned2020-05-11T13:10:38Z
dc.date.available2020-05-11T13:10:38Z
dc.date.created2016-07-15
dc.date.issued2016
dc.description.abstractBackground: For several years, cell-free DNA has been emerging as an important biomarker for non-invasive diagnostic in a wide range of clinical conditions and diseases. The limited information available on the genotoxic effects associated with occupational exposure to car paints, as well as the fact that up-to-date there are not reports about cell-free DNA measurements for assessing this condition, led us to evaluate the DNA damage caused by the occupational exposure to organic solvents contained in car paints, through the quantification of the cell-free DNA and the comet assay, in a sample of 33 individuals taken from 10 automobile paint shops located in Bogota DC, Colombia. Results: By applying the two methods, cell-free DNA and comet assay, we found a significant increase in the extent of DNA damage in the exposed individuals compared with the non-exposed ones within the control group. Conclusions: Our findings provide useful information about the cell-free DNA levels in this type of exposure and can be considered as a support tool that contributes to the diagnosis of genotoxic damage in individuals occupationally exposed to car paints. © 2016 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12995-016-0123-8
dc.identifier.issn1745-6673
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21944
dc.language.isoengspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleJournal of Occupational Medicine and Toxicology
dc.relation.citationVolumeVol. 11
dc.relation.ispartofJournal of Occupational Medicine and Toxicology, ISSN: 1745-6673 Vol. 11, No. 1 (Julio 2016); 9 ppspa
dc.relation.urihttps://occup-med.biomedcentral.com/articles/10.1186/s12995-016-0123-8spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcPromoción de saludspa
dc.subject.ddcIncidencia & prevención de la enfermedadspa
dc.subject.keywordCar paintersspa
dc.subject.keywordOrganic solventsspa
dc.subject.keywordOccupational exposurespa
dc.subject.keywordGenotoxicityspa
dc.subject.keywordCell-free DNAspa
dc.subject.keywordComet assayspa
dc.titleQuantification of cell-free DNA for evaluating genotoxic damage from occupational exposure to car paintsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
Quantification_of_cell-free_DNA_for_evaluating_genotoxic_damage_from_occupational_exposure_to_car_paints.pdf
Tamaño:
2.67 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos