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The multisystemic functions of FOXD1 in development and disease

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dc.creatorQuintero-Ronderos P.spa
dc.creatorLaissue P.spa
dc.date.accessioned2020-05-25T23:56:21Z
dc.date.available2020-05-25T23:56:21Z
dc.date.created2018spa
dc.description.abstractTranscription factors (TFs) participate in a wide range of cellular processes due to their inherent function as essential regulatory proteins. Their dysfunction has been linked to numerous human diseases. The forkhead box (FOX) family of TFs belongs to the “winged helix” superfamily, consisting of proteins sharing a related winged helix-turn-helix DNA-binding motif. FOX genes have been extensively present during vertebrates and invertebrates’ evolution, participating in numerous molecular cascades and biological functions, such as embryonic development and organogenesis, cell cycle regulation, metabolism control, stem cell niche maintenance, signal transduction, and many others. FOXD1, a forkhead TF, has been related to different key biological processes such as kidney and retina development and embryo implantation. FOXD1 dysfunction has been linked to different pathologies, thereby constituting a diagnostic biomarker and a promising target for future therapies. This paper aims to present, for the first time, a comprehensive review of FOXD1’s role in mouse development and human disease. Molecular, structural, and functional aspects of FOXD1 are presented in light of physiological and pathogenic conditions, including its role in human disease aetiology, such as cancer and recurrent pregnancy loss. Taken together, the information given here should enable a better understanding of FOXD1 function for basic science researchers and clinicians. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s00109-018-1665-2
dc.identifier.issn09462716
dc.identifier.issn14321440
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22405
dc.language.isoengspa
dc.publisherSpringer Verlagspa
dc.relation.citationEndPage739
dc.relation.citationIssueNo. 8
dc.relation.citationStartPage725
dc.relation.citationTitleJournal of Molecular Medicine
dc.relation.citationVolumeVol. 96
dc.relation.ispartofJournal of Molecular Medicine, ISSN:09462716, 14321440, Vol.96, No.8 (2018); pp. 725-739spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85049144635&doi=10.1007%2fs00109-018-1665-2&partnerID=40&md5=61bc91fe8b03d83f9ba14235817ac044spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordForkhead box D1 proteinspa
dc.subject.keywordForkhead transcription factorspa
dc.subject.keywordTranscription factorspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordForkhead transcription factorspa
dc.subject.keywordFOXD1 proteineng
dc.subject.keywordBody patterningspa
dc.subject.keywordCell proliferationspa
dc.subject.keywordCentral nervous systemspa
dc.subject.keywordGene expressionspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunohistochemistryspa
dc.subject.keywordImplantationspa
dc.subject.keywordKidney developmentspa
dc.subject.keywordMalignant neoplasmspa
dc.subject.keywordMicroarray analysisspa
dc.subject.keywordMolecular biologyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordOrganogenesisspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordPhysicianspa
dc.subject.keywordProtein functionspa
dc.subject.keywordProtein protein interactionspa
dc.subject.keywordProtein structurespa
dc.subject.keywordRecurrent abortionspa
dc.subject.keywordReproductive successspa
dc.subject.keywordRetina developmentspa
dc.subject.keywordRetina ganglion cellspa
dc.subject.keywordReviewspa
dc.subject.keywordRisk factorspa
dc.subject.keywordScientistspa
dc.subject.keywordAnimalspa
dc.subject.keywordAntibody specificityspa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordEmbryo developmentspa
dc.subject.keywordFemalespa
dc.subject.keywordGene expression regulationspa
dc.subject.keywordGeneticsspa
dc.subject.keywordMetabolismspa
dc.subject.keywordPregnancyspa
dc.subject.keywordSignal transductionspa
dc.subject.keywordAnimalsspa
dc.subject.keywordDisease Susceptibilityspa
dc.subject.keywordEmbryonic Developmentspa
dc.subject.keywordFemalespa
dc.subject.keywordForkhead Transcription Factorsspa
dc.subject.keywordGene Expression Regulationspa
dc.subject.keywordHumansspa
dc.subject.keywordOrgan Specificityspa
dc.subject.keywordOrganogenesisspa
dc.subject.keywordPregnancyspa
dc.subject.keywordSignal Transductionspa
dc.subject.keywordCancer aetiologyspa
dc.subject.keywordFOXD1spa
dc.subject.keywordKidney morphogenesisspa
dc.subject.keywordRecurrent pregnancy lossspa
dc.subject.keywordRetina developmentspa
dc.subject.keywordTranscription factorspa
dc.titleThe multisystemic functions of FOXD1 in development and diseasespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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