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HLA-Class II in Latin American patients with type 1 diabetes

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dc.creatorRojas-Villarraga, Adriana
dc.creatorBotello-Corzo, Dianaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:01:32Z
dc.date.available2020-05-26T00:01:32Z
dc.date.created2010spa
dc.description.abstractObjective: To identify and estimate the common effect size of HLA-Class II contributing to susceptibility on T1D in Latin America (LA) through a meta-analysis. Methods: A systematic review of the literature searching for all HLA-Class II alleles and susceptibility for T1D case-control studies performed in LA was made up to October 2009. Effect summary ORs and 95% CI were obtained by means of the random effect model. A prediction model that identifies peptides binding to HLA-DR alleles that were significantly associated with T1D throughout the meta-analysis was done. Results: 21 studies were included (1138 cases and 1920 controls). DRB1*0301 (OR: 9.65; 95% CI: 5.69-16.36; p less than 0.0001), DRB1*1201 (OR: 4.84; 95% CI: 1.97-11.91; p= 0.001), DQB1*0302 (OR: 4.58; 95% CI: 3.36-6.26; p less than 0.0001), DQA1*0301(OR: 3.02; 95% CI: 1.37-6.65; p= 0.0059) and DQB1*0602 (OR: 0.19; 95% CI: 0.11-0.33; p less than 0.0001), DRB1*14 (OR: 0.18; 95% CI: 0.06-0.55; p= 0.0024), and DQB1*0501 (OR: 0.47; 95% CI: 0.26-0.83; p= 0.0097) were the most significant alleles associated with T1D. DRB1*0301-DQA1*0501-DQB1*0201 (OR: 13.50; 95% CI: 3.85-47.28; p less than 0.0001) and DRB1*1301-DQB1*0603 (OR: 0.25; 95% CI: 0.1-0.65; p= 0.004) were the most significant risk and protective haplotypes associated, respectively. There were peptides binding to significantly HLA-DRB1 alleles and haplotypes found through the meta-analysis from islet cell protein tyrosine phosphatase and glutamic acid decarboxylase. Conclusions: These results strengthen the effect of HLA-Class II on T1D in LA similar to Caucasians regardless of the latitudinal gradient and admixture. The shared chemical characteristics in critical pockets could explain the predisposition to present a 'diabetogenic peptide' to T cells in this population. © 2010 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2010.05.016
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23378
dc.language.isoengspa
dc.relation.citationEndPage673
dc.relation.citationIssueNo. 10
dc.relation.citationStartPage666
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 9
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.9, No.10 (2010); pp. 666-673spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77955270294&doi=10.1016%2fj.autrev.2010.05.016&partnerID=40&md5=a43238a7692ed681e93a016a419f6f2espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGlutamate decarboxylasespa
dc.subject.keywordgeneticeng
dc.subject.keywordtype 1eng
dc.subject.keywordHla antigen class 2spa
dc.subject.keywordHla dqa1 antigenspa
dc.subject.keywordHla dqb1 antigenspa
dc.subject.keywordHla dr antigenspa
dc.subject.keywordProtein tyrosine phosphatasespa
dc.subject.keywordAntigen bindingspa
dc.subject.keywordCase control studyspa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordHaplotypespa
dc.subject.keywordHispanicspa
dc.subject.keywordHumanspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPredictionspa
dc.subject.keywordReviewspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordAutoantigensspa
dc.subject.keywordDiabetes mellituseng
dc.subject.keywordGene frequencyspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGlutamate decarboxylasespa
dc.subject.keywordHla-dr antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordLatin americaspa
dc.subject.keywordPeptide fragmentsspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtein tyrosine phosphatasesspa
dc.subject.keywordHlaspa
dc.subject.keywordLatin americaspa
dc.subject.keywordType 1 diabetesspa
dc.titleHLA-Class II in Latin American patients with type 1 diabetesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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