Ítem
Acceso Abierto

Protecting capacity against malaria of chemically defined tetramer forms based on the Plasmodium falciparum apical sushi protein as potential vaccine components

Mostrar el registro sencillo de la publicación
dc.creatorVanegas, Magnolia
dc.creatorBermudez, Adriana
dc.creatorGuerrero, Yuly Andreaspa
dc.creatorCortes-Vecino, Jesús Alfredospa
dc.creatorCurtidor, Hernandospa
dc.creatorPatarroyo, Manuel Elkinspa
dc.creatorLozano, José Manuelspa
dc.date.accessioned2020-05-26T00:02:41Z
dc.date.available2020-05-26T00:02:41Z
dc.date.created2014spa
dc.description.abstractDeveloping novel generations of subunit-based antimalarial vaccines in the form of chemically-defined macromolecule systems for multiple antigen presentation represents a classical problem in the field of vaccine development. Many efforts involving synthesis strategies leading to macromolecule constructs have been based on dendrimer-like systems, the condensation of large building blocks and conventional asymmetric double dimer constructs, all based on lysine cores. This work describes novel symmetric double dimer and condensed linear constructs for presenting selected peptide multi-copies from the apical sushi protein expressed in Plasmodium falciparum. These molecules have been proved to be safe and innocuous, highly antigenic and have shown strong protective efficacy in rodents challenged with two Plasmodium species. Insights into systematic design, synthesis and characterisation have led to such novel antigen systems being used as potential platforms for developing new anti-malarial vaccine candidates. © 2014 Elsevier Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2014.06.143
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23514
dc.language.isoengspa
dc.publisherAcademic Press Inc.spa
dc.relation.citationEndPage23
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage15
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 451
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN:0006291X, 10902104, Vol.451, No.1 (2014); pp. 15-23spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84906261632&doi=10.1016%2fj.bbrc.2014.06.143&partnerID=40&md5=79abfeaa102db26812946247a334234bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntimalarial agentspa
dc.subject.keywordfalciparumeng
dc.subject.keywordDendrimerspa
dc.subject.keywordDimerspa
dc.subject.keywordIodine 125spa
dc.subject.keywordPeptide fragmentspa
dc.subject.keywordPlasmodium falciparum apical sushi proteinspa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordProtozoal vaccinespa
dc.subject.keywordTetramerspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAminocaproic acid derivativespa
dc.subject.keywordEpitopespa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordParasite antigenspa
dc.subject.keywordPeptidespa
dc.subject.keywordSubunit vaccinespa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAntigen presenting cellspa
dc.subject.keywordArticlespa
dc.subject.keywordChemical structurespa
dc.subject.keywordControlled studyspa
dc.subject.keywordCytotoxicityspa
dc.subject.keywordDrug designspa
dc.subject.keywordDrug synthesisspa
dc.subject.keywordGene mutationspa
dc.subject.keywordHemolysisspa
dc.subject.keywordHypothesisspa
dc.subject.keywordImmunochemistryspa
dc.subject.keywordIn vitro studyspa
dc.subject.keywordIsotope labelingspa
dc.subject.keywordMacromoleculespa
dc.subject.keywordMalaria controlspa
dc.subject.keywordMerozoitespa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordParasitemiaspa
dc.subject.keywordPeptide synthesisspa
dc.subject.keywordPhysical chemistryspa
dc.subject.keywordPlasmodium berghei infectionspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPlasmodium yoelii infectionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordProtein secondary structurespa
dc.subject.keywordSequence analysisspa
dc.subject.keywordTarget cellspa
dc.subject.keywordVaccinationspa
dc.subject.keywordWestern blottingspa
dc.subject.keywordAnimalspa
dc.subject.keywordBagg albino mousespa
dc.subject.keywordChemistryspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMalariaspa
dc.subject.keywordMalariaeng
dc.subject.keywordMetabolismspa
dc.subject.keywordMolecular geneticsspa
dc.subject.keywordPathogenicityspa
dc.subject.keywordPlasmodium bergheispa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPlasmodium yoeliispa
dc.subject.keywordProtein conformationspa
dc.subject.keywordProtein multimerizationspa
dc.subject.keywordRabbitspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordRodentiaspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAminocaproatesspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigenseng
dc.subject.keywordEpitopesspa
dc.subject.keywordHumansspa
dc.subject.keywordMalariaspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMalariaeng
dc.subject.keywordMicespa
dc.subject.keywordMiceeng
dc.subject.keywordModelseng
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordPeptidesspa
dc.subject.keywordPlasmodium bergheispa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPlasmodium yoeliispa
dc.subject.keywordProtein conformationspa
dc.subject.keywordProtein multimerizationspa
dc.subject.keywordRabbitsspa
dc.subject.keywordVaccineseng
dc.subject.keywordAntimalarial-vaccinespa
dc.subject.keywordDendrimerspa
dc.subject.keywordMacromoleculespa
dc.subject.keywordPfaspspa
dc.subject.keywordPlasmodiumspa
dc.titleProtecting capacity against malaria of chemically defined tetramer forms based on the Plasmodium falciparum apical sushi protein as potential vaccine componentsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
2014_Protectingcapacityagainstmalariaofchemically.pdf
Tamaño:
2.09 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos