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Low-grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study

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dc.creatorAgostinis-Sobrinho C.A.spa
dc.creatorRamírez-Vélez R.spa
dc.creatorGarcía-Hermoso A.spa
dc.creatorMoreira C.spa
dc.creatorLopes L.spa
dc.creatorOliveira-Santos J.spa
dc.creatorAbreu S.spa
dc.creatorMota J.spa
dc.creatorSantos R.spa
dc.date.accessioned2020-05-25T23:57:56Z
dc.date.available2020-05-25T23:57:56Z
dc.date.created2018spa
dc.description.abstractBackground: Low muscular fitness (MF) and low-grade inflammation has been linked to insulin resistance (IR). Objective: To evaluate the associations between MF and a clustered score of inflammatory biomarkers on IR and to investigate the combined impact of MF and inflammation on IR in adolescents. Methods: This is a cross-sectional analysis with 529 adolescents (267 girls) aged 12 to 18 years. Pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference were assessed. Standing long-jump and isometric handgrip dynamometry were used as indicators of MF. Continuous score of clustered inflammatory biomarkers (InflaScore) (sum of Z-scores of C-reactive protein, C3, C4, fibrinogen, and leptin) and IR (homeostasis model assessment of insulin resistance [HOMA-IR] estimated from fasting serum insulin and glucose) were assessed. Results: HOMA-IR and fasting insulin were positively associated with InflaScore and negatively associated with MF, independently of age, sex, pubertal stage, socioeconomic status, adherence to the Mediterranean diet, cardiorespiratory fitness, and waist circumference. Adolescents classified as High InflaScore/Unfit showed significantly higher HOMA-IR when compared than those with High InflaScore/Fit and those with Low InflaScore/Fit (F(3,519) = 4.761, P and lt;.003), after adjustments for potential confounders. Unfit adolescents with high InflaScore had the highest odds of expressing high HOMA-IR (odds ratio, OR = 2.40, 95% confidence interval [CI]: 1.2-5.6) and insulin risk (2.53 95% CI, 1.5-5.9) when compared to those of the Low InflaScore/Fit group, after adjustments for potential confounders. Conclusion: Higher levels of MF seem to minimize the deleterious effect of inflammation on IR. © 2017 John Wiley and Sons A/S. Published by John Wiley and Sons Ltdeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/pedi.12607
dc.identifier.issn13995448
dc.identifier.issn1399543X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22775
dc.language.isoengspa
dc.publisherBlackwell Publishing Ltdspa
dc.relation.citationEndPage435
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage429
dc.relation.citationTitlePediatric Diabetes
dc.relation.citationVolumeVol. 19
dc.relation.ispartofPediatric Diabetes, ISSN:13995448, 1399543X, Vol.19, No.3 (2018); pp. 429-435spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85045933488&doi=10.1111%2fpedi.12607&partnerID=40&md5=45f9d23184e62214f60a69e50cb1843dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordC reactive proteinspa
dc.subject.keywordComplement component C3spa
dc.subject.keywordComplement component C4spa
dc.subject.keywordFibrinogenspa
dc.subject.keywordGlucosespa
dc.subject.keywordInsulinspa
dc.subject.keywordLeptinspa
dc.subject.keywordBiological markerspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgespa
dc.subject.keywordArticlespa
dc.subject.keywordCardiorespiratory fitnessspa
dc.subject.keywordChildspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCross-sectional studyspa
dc.subject.keywordDevelopmental stagespa
dc.subject.keywordDiet restrictionspa
dc.subject.keywordDisease markerspa
dc.subject.keywordDisease severityspa
dc.subject.keywordDynamometryspa
dc.subject.keywordFeeding behaviorspa
dc.subject.keywordFemalespa
dc.subject.keywordFitnessspa
dc.subject.keywordHand gripspa
dc.subject.keywordHomeostasis model assessmentspa
dc.subject.keywordHumanspa
dc.subject.keywordInflammationspa
dc.subject.keywordInsulin blood levelspa
dc.subject.keywordInsulin resistancespa
dc.subject.keywordIsometric exercisespa
dc.subject.keywordJumpingspa
dc.subject.keywordLongitudinal studyspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMediterranean dietspa
dc.subject.keywordMuscle functionspa
dc.subject.keywordMuscular fitnessspa
dc.subject.keywordPhysical activityspa
dc.subject.keywordPriority journalspa
dc.subject.keywordPubertyspa
dc.subject.keywordSchool childspa
dc.subject.keywordScoring systemspa
dc.subject.keywordSexspa
dc.subject.keywordSocial statusspa
dc.subject.keywordStandingspa
dc.subject.keywordWaist circumferencespa
dc.subject.keywordBloodspa
dc.subject.keywordClinical trialspa
dc.subject.keywordHand strengthspa
dc.subject.keywordInflammationspa
dc.subject.keywordMulticenter studyspa
dc.subject.keywordProspective studyspa
dc.subject.keywordAdolescentspa
dc.subject.keywordBiomarkersspa
dc.subject.keywordChildspa
dc.subject.keywordCross-Sectional Studiesspa
dc.subject.keywordFemalespa
dc.subject.keywordHand Strengthspa
dc.subject.keywordHumansspa
dc.subject.keywordInflammationspa
dc.subject.keywordInsulin Resistancespa
dc.subject.keywordMalespa
dc.subject.keywordPhysical Fitnessspa
dc.subject.keywordProspective Studiesspa
dc.subject.keywordHandgripspa
dc.subject.keywordInflammationspa
dc.subject.keywordInsulin resistancespa
dc.subject.keywordStrengthspa
dc.subject.keywordYouthspa
dc.titleLow-grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Studyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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