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Anti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family members

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dc.creatorKrause, Ilanspa
dc.creatorAnaya, Juan-Manuel
dc.creatorFraser, Abigailspa
dc.creatorBarzilai, Orispa
dc.creatorRam, Mayaspa
dc.creatorAbad, Verónicaspa
dc.creatorArango, Alvarospa
dc.creatorGarcía, Jorgespa
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-05-25T23:56:06Z
dc.date.available2020-05-25T23:56:06Z
dc.date.created2009spa
dc.description.abstractType 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P = 0.01), cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue transglutaminase antibodies (P = 0.03), and a borderline association with anticentromere antibodies (P = 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies. © 2009 New York Academy of Sciences.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/j.1749-6632.2009.04619.x
dc.identifier.issn778923
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22322
dc.language.isoengspa
dc.publisherBlackwell Publishing Inc.spa
dc.relation.citationEndPage639
dc.relation.citationStartPage633
dc.relation.citationTitleAnnals of the New York Academy of Sciences
dc.relation.citationVolumeVol. 1173
dc.relation.ispartofAnnals of the New York Academy of Sciences, ISSN:778923, Vol.1173,(2009); pp. 633-639spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-69949184384&doi=10.1111%2fj.1749-6632.2009.04619.x&partnerID=40&md5=cb5ca52b4678c39a4d4eeb04e58bf50fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordBacterium antibodyspa
dc.subject.keywordCardiolipin antibodyspa
dc.subject.keywordCentromere antibodyspa
dc.subject.keywordCytomegalovirus antibodyspa
dc.subject.keywordDouble stranded dna antibodyspa
dc.subject.keywordEpstein barr virus antibodyspa
dc.subject.keywordGliadin antibodyspa
dc.subject.keywordGlomerulus basement membrane antibodyspa
dc.subject.keywordHelicobacter pylori antibodyspa
dc.subject.keywordHepatitis b virus antibodyspa
dc.subject.keywordImmunoglobulin aspa
dc.subject.keywordImmunoglobulin gspa
dc.subject.keywordImmunoglobulin g antibodyspa
dc.subject.keywordJo 1 antibodyspa
dc.subject.keywordLa antibodyspa
dc.subject.keywordMyeloperoxidase antibodyspa
dc.subject.keywordProtein glutamine gamma glutamyltransferase antibodyspa
dc.subject.keywordProteinase 3 antibodyspa
dc.subject.keywordProthrombin antibodyspa
dc.subject.keywordProtozoon antibodyspa
dc.subject.keywordRibonucleoprotein antibodyspa
dc.subject.keywordRo antibodyspa
dc.subject.keywordRubella antibodyspa
dc.subject.keywordScl 70 antibodyspa
dc.subject.keywordSm antibodyspa
dc.subject.keywordToxoplasma antibodyspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordVirus antibodyspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAge distributionspa
dc.subject.keywordAntibody blood levelspa
dc.subject.keywordCeliac diseasespa
dc.subject.keywordConference paperspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCytomegalovirusspa
dc.subject.keywordDiabetic patientspa
dc.subject.keywordDisease associationspa
dc.subject.keywordEpstein barr virusspa
dc.subject.keywordFamilyspa
dc.subject.keywordFemalespa
dc.subject.keywordHelicobacter pylorispa
dc.subject.keywordHepatitis b virusspa
dc.subject.keywordHepatitis c virusspa
dc.subject.keywordHumanspa
dc.subject.keywordInfection sensitivityspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordNonhumanspa
dc.subject.keywordRubellaspa
dc.subject.keywordToxoplasmaspa
dc.subject.keywordTreponema pallidumspa
dc.subject.keywordCytomegalovirusspa
dc.subject.keywordHelicobacter pylorispa
dc.subject.keywordHuman herpesvirus 4spa
dc.subject.keywordToxoplasmaspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCeliac diseasespa
dc.subject.keywordCytomegalovirusspa
dc.subject.keywordEpstein-barr virusspa
dc.subject.keywordHelicobacter pylorispa
dc.subject.keywordInfectionspa
dc.subject.keywordToxoplasmaspa
dc.titleAnti-infectious antibodies and autoimmune-associated autoantibodies in patients with type i diabetes mellitus and their close family membersspa
dc.typeconferenceObjecteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaDocumento de conferenciaspa
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