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ZC3H12A (MCPIP1): Molecular characteristics and clinical implications

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dc.creatorCifuentes, Ricardo A.spa
dc.creatorCruz-Tapias, Paolaspa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:04:10Z
dc.date.available2020-05-26T00:04:10Z
dc.date.created2010spa
dc.description.abstractBackground: ZC3H12A is a gene whose absence is related to autoimmune disorders and to other phenotypical alterations. Methods: A comprehensive review of the structure, molecular functions and regulation of ZC3H12A gene and its protein MCPIP1 is done in order to understand their clinical implications. Results: ZC3H12A, at 1p34.3, has 9860 bp, six exons and 61 described SNPs. Eleven are non-synonymous thus leading to changes in MCPIP1, the protein encoded by ZC3H12A. MCPIP1 is induced by MCP-1 and IL-1 whose signals are transduced through the NF-k? and MAPkinase pathways. This protein acts as an RNAse by degrading chemokine transcripts such as IL-1 as well as its own mRNA and as a transcription factor by reducing the expression of other chemokines induced by NF-k? such as MCP-1. It also up-regulates genes involved in several differentiation processes and apoptosis. Therefore, ZC3H12A is an equilibrium gatekeeper that not only regulates its own inducers but also controls the regulation by degrading its own mRNA. Conclusion: Understanding ZC3H12A gives a comprehensive panorama that promises to improve our understanding of processes in which this gene is involved including autoimmune, infectious and cardiovascular diseases. © 2010 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.cca.2010.08.033
dc.identifier.issn98981
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23664
dc.language.isoengspa
dc.relation.citationEndPage1868
dc.relation.citationIssueNo. 23-24
dc.relation.citationStartPage1862
dc.relation.citationTitleClinica Chimica Acta
dc.relation.citationVolumeVol. 411
dc.relation.ispartofClinica Chimica Acta, ISSN:98981, Vol.411, No.23-24 (2010); pp. 1862-1868spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77957754481&doi=10.1016%2fj.cca.2010.08.033&partnerID=40&md5=5584894f3101666d64f6031940c88bdcspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordImmunoglobulin enhancer binding proteinspa
dc.subject.keywordInterleukin 1spa
dc.subject.keywordMessenger rnaspa
dc.subject.keywordMitogen activated protein kinasespa
dc.subject.keywordMonocyte chemotactic protein 1spa
dc.subject.keywordMonocyte chemotactic protein 1 induced proteinspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordZinc finger proteinspa
dc.subject.keywordApoptosisspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordCardiovascular diseasespa
dc.subject.keywordGene controlspa
dc.subject.keywordGene functionspa
dc.subject.keywordGene structurespa
dc.subject.keywordGenetic regulationspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHumanspa
dc.subject.keywordInfectionspa
dc.subject.keywordMolecular geneticsspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein degradationspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordProtein functionspa
dc.subject.keywordReviewspa
dc.subject.keywordSignal transductionspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordUpregulationspa
dc.subject.keywordAnimalsspa
dc.subject.keywordDiseasespa
dc.subject.keywordHumansspa
dc.subject.keywordTranscription factorsspa
dc.subject.keywordPyronia tithonusspa
dc.subject.keywordApoptosisspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordCardiac diseasesspa
dc.subject.keywordGeneticsspa
dc.subject.keywordMcpip1spa
dc.subject.keywordZc3h12aspa
dc.titleZC3H12A (MCPIP1): Molecular characteristics and clinical implicationsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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