Ítem
Solo Metadatos

The diagnosis and clinical significance of polyautoimmunity

Mostrar el registro sencillo de la publicación
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:00:19Z
dc.date.available2020-05-26T00:00:19Z
dc.date.created2014spa
dc.description.abstractAutoimmune diseases (ADs) are chronic and heterogeneous conditions that affect specific target organs or multiple organ systems. The chronic nature of these diseases places a significant burden on the utilization of medical care, direct and indirect economic costs, and quality of life. ADs are observed in genetically susceptible individuals in whom their clinical expression is modified by permissive and protective environments occurring over time. These are complex traits, meaning that their inheritance does not follow a single-gene dominant or single-gene recessive Mendelian law, and thus that they are polygenic. ADs are often diagnosed according to classification criteria, however they share similar subphenotypes including signs and symptoms, non-specific autoantibodies and other immune changes, which are prone to taxonomic problems. Polyautoimmunity is defined as the presence of more than one AD in a single patient. When three or more ADs coexist, this condition is called multiple autoimmune syndrome (MAS), which represents the best example of polyautoimmunity as well as the effect of a single genotype on diverse autoimmune phenotypes. Its study will provide important clues to elucidate the common mechanisms of ADs (i.e., the autoimmune tautology). © 2014 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2014.01.049
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23199
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage426
dc.relation.citationIssueNo. 43955
dc.relation.citationStartPage423
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 13
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.13, No.43955 (2014); pp. 423-426spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84896316752&doi=10.1016%2fj.autrev.2014.01.049&partnerID=40&md5=11a5c2ff2d08cec695f96df094ed7520spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordAddison diseasespa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmune hemolytic anemiaspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCeliac diseasespa
dc.subject.keywordDominant genespa
dc.subject.keywordFollow upspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumanspa
dc.subject.keywordHypoparathyroidismspa
dc.subject.keywordIdiopathic thrombocytopenic purpuraspa
dc.subject.keywordInheritancespa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMixed connective tissue diseasespa
dc.subject.keywordMultiple autoimmune syndromespa
dc.subject.keywordMyasthenia gravisspa
dc.subject.keywordPernicious anemiaspa
dc.subject.keywordPhenotypespa
dc.subject.keywordPhysical disease by body functionspa
dc.subject.keywordPolyautoimmunityspa
dc.subject.keywordRecessive inheritancespa
dc.subject.keywordReviewspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordThrushspa
dc.subject.keywordThymomaspa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordPhenotypespa
dc.titleThe diagnosis and clinical significance of polyautoimmunityspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos