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The insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and metaanalysis

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dc.contributor.gruplacCentro de Estudios en Medición de la Actividad Física (CEMA)spa
dc.creatorMeneses Echávez, José Francisco
dc.creatorGonzález Jiménez, Emilio
dc.creatorSchmidt Rio-Valle, Jacqueline
dc.creatorCorrea Bautista, Jorge Enrique
dc.creatorRamírez-Vélez, Robinson
dc.creatorIzquierdo, Mikel
dc.creator.googleMeneses Echávez, Jose Francisco
dc.creator.googleGonzález Jiménez, Emilio
dc.creator.googleSchmidt Rio-Valle, Jacqueline
dc.creator.googleCorrea Bautista, Jorge Enrique
dc.creator.googleIzquierdo, Mikel
dc.creator.googleRamírez-Vélez, Robinson
dc.date.accessioned2018-02-21T20:08:13Z
dc.date.available2018-02-21T20:08:13Z
dc.date.created2016
dc.date.issued2016
dc.description.abstractBackground: Insulin-like growth factors (IGF´s) play a crucial role in controlling cancer cell proliferation, differentiation and apoptosis. Exercise has been postulated as an effective intervention in improving cancerrelated outcomes and survival, although its effects on IGF´s are not well understood. This meta-analysis aimed to determine the effects of exercise in modulating IGF´s system in breast cancer survivors. Methods: Databases of PuMed, EMBASE, Cochrane Central Register of Controlled Trials, EMBASE, ClinicalTrials. gov, SPORTDiscus, LILACS and Scopus were systematically searched up to November 2014. Effect estimates were calculated through a random-effects model of meta-analysis according to the DerSimonian and Laird method. Heterogeneity was evaluated with the I 2 test. Risk of bias and methodological quality were evaluated using the PEDro score. Results: Five randomized controlled trials (n = 235) were included. Most women were post-menopausal. Highquality and low risk of bias were found (mean PEDro score = 6.2 ± 1). Exercise resulted in significant improvements on IGF-I, IGF-II, IGFBP-I, IGFBP-3, Insulin and Insulin resistance (P 0.05). Non-significant differences were found for Glucose. Aerobic exercise improved IGF-I, IGFBP-3 and Insulin. No evidence of publication bias was detected by Egger´s test (p = 0.12). Conclusions: Exercise improved IGF´s in breast cancer survivors. These findings provide novel insight regarding the molecular effects of exercise on tumoral microenvironment, apoptosis and survival in breast cancer survivors.eng
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/14426
dc.language.isoeng
dc.relation.citationEndPage10
dc.relation.citationStartPage2
dc.relation.citationTitleBMC Cancer
dc.relation.ispartofBMC Cancer, ISSN 1471-2407, (2016); pp. 2-10spa
dc.relation.urihttps://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2733-z
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://www.sap.org.ar/publicaciones/contenidos/28/consentimiento-informado.html
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectBreast Cancerspa
dc.subjectExercisespa
dc.subjectInsulin-Like Growth Factor Binding Proteinsspa
dc.subjectTumor Microenvironmentspa
dc.subject.ddcFisiología humana
dc.subject.lembCáncerspa
dc.titleThe insulin-like growth factor system is modulated by exercise in breast cancer survivors: a systematic review and metaanalysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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