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A New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRS

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dc.creatorCaicedo Dorado, Alexander
dc.creatorAlderliesten, Thomasspa
dc.creatorNaulaers, Gunnarspa
dc.creatorLemmers, Petraspa
dc.creatorVan Bel, Frankspa
dc.creatorVan Huffel, Sabinespa
dc.date.accessioned2020-08-28T15:49:59Z
dc.date.available2020-08-28T15:49:59Z
dc.date.created2016spa
dc.description.abstractWe present a new framework for the assessment of cerebral hemodynamics regulation (CHR) in neonates using near-infrared spectroscopy (NIRS). In premature infants, NIRS measurements have been used as surrogate variables for cerebral blood flow (CBF) in the assessment of cerebral autoregulation (CA). However, NIRS measurements only reflect changes in CBF under constant changes in arterial oxygen saturation (SaO2). This condition is unlikely to be met at the bedside in the NICU. Additionally, CA is just one of the different highly coupled mechanisms that regulate brain hemodynamics. Traditional methods for the assessment of CA do not take into account the multivariate nature of CHR, producing inconclusive results. In this study we propose a newly developed multivariate methodology for the assessment of CHR. This method is able to effectively decouple the influences of SaO2 from the NIRS measurements, and at the same time, produces scores indicating the strength of the coupling between the systemic variables and NIRS recordings. We explore the use of this method, and its derived scores, for the monitoring of CHR using data from premature infants who developed a grade III-IV intra-ventricular hemorrhage during the first 3 days of life.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/978-1-4939-3023-4_63
dc.identifier.issnISBN: 978-1-4939-3022-7
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28876
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage509
dc.relation.citationStartPage501
dc.relation.citationTitleAdvances in Experimental Medicine and Biology
dc.relation.citationVolumeVol. 876
dc.relation.ispartofAdvances in Experimental Medicine and Biology, ISBN: 978-1-4939-3022-7, Vol.876 (2016); pp. 501-509spa
dc.relation.urihttps://link.springer.com/chapter/10.1007/978-1-4939-3023-4_63spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceAdvances in Experimental Medicine and Biologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordCerebral autoregulationspa
dc.subject.keywordNIRSspa
dc.subject.keywordMultivariablespa
dc.subject.keywordPremature infantsspa
dc.titleA New Framework for the Assessment of Cerebral Hemodynamics Regulation in Neonates Using NIRSspa
dc.title.TranslatedTitleUn nuevo marco para la evaluación de la regulación de la hemodinámica cerebral en recién nacidos mediante NIRSspa
dc.typebookParteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaParte de librospa
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