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Effects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: A systematic review and Meta-analysis

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dc.creatorRamírez-Vélez, Robinson
dc.creatorGarcía-Hermoso, Antoniospa
dc.creatorHackney, Anthony C.spa
dc.creatorIzquierdo, Mikelspa
dc.date.accessioned2020-05-25T23:56:51Z
dc.date.available2020-05-25T23:56:51Z
dc.date.created2019spa
dc.description.abstractBackground: Elevated levels of fetuin-A are associated with increased risks of metabolic syndrome, type 2 diabetes and nonalcoholic fatty liver disease. This meta-analysis investigated whether exercise interventions can reduce fetuin-A in adults. Methods: We searched clinical trials that objectively assessed fetuin-A and included study arms with exercise intervention. The pre-intervention and post-intervention data were used for meta-analysis. The effect sizes were calculated as standardized mean differences or changes in fetuin-A and expressed as Hedges' g using random-effects models. Results: The overall Hedges' g for fetuin-A in all included interventions was - 0.640 (95%CI - 1.129 to - 0.151; n = 9), but this effect was not observed in obese (g = - 0.096; 95%CI, - 0.328 to 0.135) and type 2 diabetes/dysglycemia (g = - 0.56; 95%CI, - 1.348 to 0.236) individuals. Additionally, the random-effects meta-regression analysis showed that there was not a greater decrease in fetuin-A in individuals who achieved greater body mass index reductions (regression coefficient = 0.065; 95%CI, - 0.185 to 0.315). Conclusion: Supervised exercise is associated with reductions in fetuin-A levels in adults and elderly. However, the results of the present meta-analysis should be interpreted with caution because of the variety of type of exercises and individual obesity related-disorders involve. Therefore, additional high-quality randomized controlled trials describing the effect of supervised exercise interventions on fetuin-A in adults are still needed. © 2019 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12944-019-0962-2
dc.identifier.issn1476511X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22540
dc.language.isoengspa
dc.publisherBioMed Central Ltd.spa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleLipids in Health and Disease
dc.relation.citationVolumeVol. 18
dc.relation.ispartofLipids in Health and Disease, ISSN:1476511X, Vol.18, No.1 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060389892&doi=10.1186%2fs12944-019-0962-2&partnerID=40&md5=e88eea99a9d4dd405b0742b879e9f81dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordFetuin Aspa
dc.subject.keywordType 2eng
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordBody massspa
dc.subject.keywordCardiovascular diseasespa
dc.subject.keywordClinical assessmentspa
dc.subject.keywordClinical effectivenessspa
dc.subject.keywordClinical evaluationspa
dc.subject.keywordClinical protocolspa
dc.subject.keywordDisease associationspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordExercisespa
dc.subject.keywordExercise intensityspa
dc.subject.keywordHumanspa
dc.subject.keywordMeta analysisspa
dc.subject.keywordNon insulin dependent diabetes mellitusspa
dc.subject.keywordObesityspa
dc.subject.keywordProtein blood levelspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordReviewspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordMetabolismspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordNon insulin dependent diabetes mellitusspa
dc.subject.keywordObesityspa
dc.subject.keywordPublishingspa
dc.subject.keywordRandomized controlled trial (topic)spa
dc.subject.keywordRegression analysisspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAlpha-2-HS-Glycoproteinspa
dc.subject.keywordDiabetes Mellituseng
dc.subject.keywordExercisespa
dc.subject.keywordHumansspa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordObesityspa
dc.subject.keywordPublication Biasspa
dc.subject.keywordRandomized Controlled Trials as Topicspa
dc.subject.keywordRegression Analysisspa
dc.subject.keywordRisk Factorsspa
dc.subject.keywordCardiovascular diseasespa
dc.subject.keywordExercise trainingspa
dc.subject.keywordFetuin-aspa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordMetabolic syndromespa
dc.subject.keywordObesityspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordType 2 diabetesspa
dc.titleEffects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: A systematic review and Meta-analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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