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A factorial randomized controlled trial to evaluate the effect of micronutrients supplementation and regular aerobic exercise on maternal endothelium-dependent vasodilatation and oxidative stress of the newborn

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dc.creatorRamírez-Vélez, Robinsonspa
dc.creatorRomero, Miryamspa
dc.creatorEcheverri, Isabellaspa
dc.creatorOrtega, José Guillermospa
dc.creatorMosquera, Mildreyspa
dc.creatorSalazar, Blancaspa
dc.creatorGirón, Sandra Lorenaspa
dc.creatorSaldarriaga, Wilmarspa
dc.creatorAguilar de Plata, Ana Ceciliaspa
dc.creatorMateus, Julio Cesarspa
dc.date.accessioned2020-08-19T14:42:07Z
dc.date.available2020-08-19T14:42:07Z
dc.date.created2011-02-28spa
dc.description.abstractBackground Many studies have suggested a relationship between metabolic abnormalities and impaired fetal growth with the development of non-transmissible chronic diseases in the adulthood. Moreover, it has been proposed that maternal factors such as endothelial function and oxidative stress are key mechanisms of both fetal metabolic alterations and subsequent development of non-transmissible chronic diseases. The objective of this project is to evaluate the effect of micronutrient supplementation and regular aerobic exercise on endothelium-dependent vasodilation maternal and stress oxidative of the newborn. Methods and design 320 pregnant women attending to usual prenatal care in Cali, Colombia will be included in a factorial randomized controlled trial. Women will be assigned to the following intervention groups: 1. Control group: usual prenatal care (PC) and placebo (maltodextrine). 2. Exercise group: PC, placebo and aerobic physical exercise. 3. Micronutrients group: PC and a micronutrients capsule consisting of zinc (30 mg), selenium (70 ?g), vitamin A (400 ?g), alphatocopherol (30 mg), vitamin C (200 mg), and niacin (100 mg). 4. Combined interventions Group: PC, supplementation of micronutrients, and aerobic physical exercise. Anthropometric measures will be taken at the start and at the end of the interventions. Discussion Since in previous studies has been showed that the maternal endothelial function and oxidative stress are related to oxidative stress of the newborn, this study proposes that complementation with micronutrients during pregnancy and/or regular physical exercise can be an early and innovative alternative to strengthen the prevention of chronic diseases in the population.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/1745-6215-12-60
dc.identifier.issnISSN: 1468-6708
dc.identifier.issnEISSN: 1745-6215
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27420
dc.language.isoengspa
dc.publisherBioMed Centralspa
dc.relation.citationIssueNo. 60
dc.relation.citationTitleTrials, Current Controlled Trials in Cardiovascular Medicine
dc.relation.citationVolumeVol. 12
dc.relation.ispartofTrials, Current Controlled Trials in Cardiovascular Medicine, ISSN: 1468-6708;EISSN: 1745-6215 , Vol.12, No.60 (2011); 8 pp. spa
dc.relation.urihttps://trialsjournal.biomedcentral.com/track/pdf/10.1186/1745-6215-12-60spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceTrials, Current Controlled Trials in Cardiovascular Medicinespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPrenatal carespa
dc.subject.keywordBrachial arteryspa
dc.subject.keywordUmbilical cord bloodspa
dc.subject.keywordMean blood pressurespa
dc.subject.keywordMicronutrient supplementationspa
dc.titleA factorial randomized controlled trial to evaluate the effect of micronutrients supplementation and regular aerobic exercise on maternal endothelium-dependent vasodilatation and oxidative stress of the newbornspa
dc.title.TranslatedTitleUn ensayo controlado aleatorio factorial para evaluar el efecto de la suplementación con micronutrientes y el ejercicio aeróbico regular sobre la vasodilatación dependiente del endotelio materno y el estrés oxidativo del recién nacidospa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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