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Interrelationship Between Broadband NIRS Measurements of Cerebral Cytochrome C Oxidase and Systemic Changes Indicates Injury Severity in Neonatal Encephalopathy

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dc.creatorCaicedo Dorado, Alexander
dc.creatorTachtsidis, Iliasspa
dc.creatorRobertson, Nicolaspa
dc.creatorMee, Judithspa
dc.creatorChan, Marcusspa
dc.creatorde Roever, Isabelspa
dc.creatorMitra, Subhabrataspa
dc.creatorBale, Gemmaspa
dc.date.accessioned2020-08-28T15:50:00Z
dc.date.available2020-08-28T15:50:00Z
dc.date.created2016-08-16spa
dc.description.abstractPerinatal hypoxic ischaemic encephalopathy (HIE) is associated with severe neurodevelopmental problems and mortality. There is a clinical need for techniques to provide cotside assessment of the injury extent. This study aims to use non-invasive cerebral broadband near-infrared spectroscopy (NIRS) in combination with systemic physiology to assess the severity of HIE injury. Broadband NIRS is used to measure the changes in haemodynamics, oxygenation and the oxidation state of cytochrome c oxidase (oxCCO). We used canonical correlation analysis (CCA), a multivariate statistical technique, to measure the relationship between cerebral broadband NIRS measurements and systemic physiology. A strong relationship between the metabolic marker, oxCCO, and systemic changes indicated severe brain injury; if more than 60?% of the oxCCO signal could be explained by the systemic variations, then the neurodevelopmental outcome was poor. This boundary has high sensitivity and specificity (100 and 83?%, respectively). Broadband NIRS measured concentration changes of the oxidation state of cytochrome c oxidase has the potential to become a useful cotside tool for assessment of injury severity following hypoxic ischaemic brain injury.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/978-3-319-38810-6_24
dc.identifier.issnISBN: 978-3-319-38808-3
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28881
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage186
dc.relation.citationStartPage181
dc.relation.citationTitleAdvances in Experimental Medicine and Biology
dc.relation.citationVolumeVol. 923
dc.relation.ispartofAdvances in Experimental Medicine and Biology, ISBN: 978-3-319-38808-3, Vol.923 (2016); pp. 181-186spa
dc.relation.urihttps://link.springer.com/content/pdf/10.1007%2F978-3-319-38810-6_24.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceAdvances in Experimental Medicine and Biologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordNear-infrared spectroscopyspa
dc.subject.keywordCytochrome c oxidasespa
dc.subject.keywordHypoxic ischaemic encephalopathyspa
dc.subject.keywordNeonatalspa
dc.subject.keywordOxygen metabolismspa
dc.titleInterrelationship Between Broadband NIRS Measurements of Cerebral Cytochrome C Oxidase and Systemic Changes Indicates Injury Severity in Neonatal Encephalopathyspa
dc.title.TranslatedTitleLa interrelación entre las mediciones NIRS de banda ancha de la citocromo C oxidasa cerebral y los cambios sistémicos indican la gravedad de la lesión en la encefalopatía neonatalspa
dc.typebookParteng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaParte de librospa
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