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Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: Retrospective pooled analysis of trial data

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dc.audienceComunidad Rosaristaspa
dc.creatorJoura, Elmar A
dc.creatorGarland, Suzanne M
dc.creatorPaavonen, Jorma
dc.creatorFerris, Daron G
dc.creatorPerez, Gonzalo
dc.creatorAult, Kevin
dc.creatorHuh, Warner K
dc.creatorSings, Heather L
dc.creatorJames, Margaret K.
dc.creatorHaupt, Richard M
dc.creator.googleJoura, Elmar A
dc.creator.googleGarland, Suzanne M
dc.creator.googlePaavonen, Jorma
dc.creator.googleFerris, Daron G
dc.creator.googlePerez, Gonzalo
dc.creator.googleAult, Kevin A
dc.creator.googleHuh, Warner K
dc.creator.googleSings, Heather L
dc.creator.googleJames, Margaret K.
dc.creator.googleHaupt, Richard M
dc.date.accessioned2014-08-12T12:46:06Z
dc.date.available2014-08-12T12:46:06Z
dc.date.created2012
dc.date.issued2012
dc.description.abstractObjectives To determine the effect of human papillomavirus (HPV) quadrivalent vaccine on the risk of developing subsequent disease after an excisional procedure for cervical intraepithelial neoplasia or diagnosis of genital warts, vulvar intraepithelial neoplasia, or vaginal intraepithelial neoplasia. Design Retrospective analysis of data from two international, double blind, placebo controlled, randomised efficacy trials of quadrivalent HPV vaccine (protocol 013 (FUTURE I) and protocol 015 (FUTURE II)). Setting Primary care centres and university or hospital associated health centres in 24 countries and territories around the world. Participants Among 17 622 women aged 15–26 years who underwent 1:1 randomisation to vaccine or placebo, 2054 received cervical surgery or were diagnosed with genital warts, vulvar intraepithelial neoplasia, or vaginal intraepithelial neoplasia. Intervention Three doses of quadrivalent HPV vaccine or placebo at day 1, month 2, and month 6. Main outcome measures Incidence of HPV related disease from 60 days after treatment or diagnosis, expressed as the number of women with an end point per 100 person years at risk. Results A total of 587 vaccine and 763 placebo recipients underwent cervical surgery. The incidence of any subsequent HPV related disease was 6.6 and 12.2 in vaccine and placebo recipients respectively (46.2% reduction (95% confidence interval 22.5% to 63.2%) with vaccination). Vaccination was associated with a significant reduction in risk of any subsequent high grade disease of the cervix by 64.9% (20.1% to 86.3%). A total of 229 vaccine recipients and 475 placebo recipients were diagnosed with genital warts, vulvar intraepithelial neoplasia, or vaginal intraepithelial neoplasia, and the incidence of any subsequent HPV related disease was 20.1 and 31.0 in vaccine and placebo recipients respectively (35.2% reduction (13.8% to 51.8%)). Conclusions Previous vaccination with quadrivalent HPV vaccine among women who had surgical treatment for HPV related disease significantly reduced the incidence of subsequent HPV related disease, including high grade disease.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.issnISSN:17561833
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8780
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 7851
dc.relation.citationTitleBMJ
dc.relation.citationVolumeVol. 344
dc.relation.ispartofBMJ (Online) ISSN: 17561833 V. 344 N. 7851 Abr 2012spa
dc.relation.urihttp://www.bmj.com.ez.urosario.edu.co/content/344/bmj.e1401.pdf%2Bhtml
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcGinecología & otras especialidades médicas
dc.subject.decsCrioterapiaspa
dc.subject.decsFarmacologíaspa
dc.subject.decsCondiloma acuminadospa
dc.subject.decsVirus del papiloma humano. VPHspa
dc.subject.keywordadolescenteng
dc.subject.keywordadulteng
dc.subject.keywordarticleeng
dc.subject.keywordcondyloma acuminatumeng
dc.subject.keywordcontrolled studyeng
dc.subject.keywordcryotherapyeng
dc.subject.keyworddisease associationeng
dc.subject.keyworddisease courseeng
dc.subject.keyworddrug efficacyeng
dc.titleEffect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: Retrospective pooled analysis of trial dataspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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