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MHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversity

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dc.creatorCardenas, Paula P.spa
dc.creatorSuarez, Carlos F.spa
dc.creatorMartinez, Pilarspa
dc.creatorPatarroyo, Manuel E.spa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-08-06T16:21:11Z
dc.date.available2020-08-06T16:21:11Z
dc.date.created2005-01-15spa
dc.description.abstractThe MHC class I molecule plays an important role in immune response, pathogen recognition and response against vaccines and self- versus non-self-recognition. Studying MHC class I characteristics thus became a priority when dealing with Aotus to ensure its use as an animal model for biomedical research. Isolation, cloning and sequencing of exons 1–8 from 27 MHC class I alleles obtained from 13 individuals classified as belonging to three owl monkey species (A. nancymaae, A. nigriceps and A. vociferans) were carried out to establish similarities between Aotus MHC class I genes and those expressed by other New and Old World primates. Six Aotus MHC class I sequence groups (Ao-g1, Ao-g2, Ao-g3, Ao-g4, Ao-g5 and Ao-g6) weakly related to non-classical Catarrhini MHC were identified. An allelic lineage was also identified in one A. nancymaae and two A. vociferans monkeys, exhibiting a high degree of conservation, negative selection along the molecule and premature termination of the open reading frame at exon 5 (Ao-g5). These sequences’ high conservation suggests that they more likely correspond to a soluble form of Aotus MHC class I molecules than to a new group of processed pseudogenes. Another group, named Ao-g6, exhibited a strong relationship with Catarrhini’s classical MHC-B-C loci. Sequence evolution and variability analysis indicated that Aotus MHC class I molecules experience inter-locus gene conversion phenomena, contributing towards their high variabilityeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s00251-004-0751-5
dc.identifier.issnISSN: 0093-7711
dc.identifier.issnEISSN: 1432-1211
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26280
dc.language.isoengspa
dc.publisherSpringer Naturespa
dc.relation.citationEndPage832
dc.relation.citationStartPage818
dc.relation.citationTitleImmunogenetics
dc.relation.citationVolumeVol. 56
dc.relation.ispartofImmunogenetics, ISSN:0093-7711;EISSN:1432-1211, Vol.56, (January, 2005); pp.818-832spa
dc.relation.urihttps://link.springer.com/article/10.1007/s00251-004-0751-5spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceImmunogeneticsspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordAotusspa
dc.subject.keywordMHC class I moleculesspa
dc.subject.keywordGene conversionspa
dc.subject.keywordEvolutionspa
dc.titleMHC class I genes in the owl monkey: Mosaic organisation, convergence and loci diversityspa
dc.title.TranslatedTitleGenes MHC de clase I en el mono búho: organización mosaica, convergencia y diversidad de locispa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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